Astragaloside IV, the main component of the traditional Chinese medicine astragalus membra-naceus, has been shown to inhibit inflammation, oxidation, and apoptosis, and exerts immu-noregulatory effects.
Astragaloside IV is one of the main active compounds of Astragalus membranaceus Bunge. Experimental studies from several laboratories,have provided abundant evidence demonstrating the explicit cardiovascular-protective effects of Astragaloside IV(CAS NO:84687-43-4).
Now, let’s talk about what can we benefit from Astragaloside IV in detail.
1.Immunostimulant: acting through a number of different pathways, especially,by increasing the number of stem cells in the spinal cord and lymphatic tissue and encouraging them to develop into active immune cells or stimulating production of immunoglobulins and macrophages.
2.Neuroprotective: in traditional Chinese medicine, astragalus root extract is used to treat neurodegenerative diseases. One study demonstrated the capacity of astragaloside IV(CAS NO:84687-43-4) to protect dopaminergic neurons (progressive degeneration of dopaminergic neurons leads to the development of Parkinson's disease).
3.Antibacterial: as demonstrated by in vitro studies on Shigella dysenteriae, Streptococcus haemolyticus, Diplococcus pneumoniae and Staphylococcus aureus.
4.Antiviral: inhibiting replication of certain viruses such as coxsackie, responsible for myocarditis (inflammation of the heart muscle). In both animal and human studies, they were shown to stimulate endogenous interferon production and to maximise its effect on viral infections.
5.Anti-inflammatory: as shown in certain animal models. The ability of astragaloside IV to stem inflammation of the airways in chronic asthma has been reported in studies on mice.
6.Inhibitory: against formation of the AGEs involved in neuropathic complications of diabetes.
7.Protective: against the toxic effects of chemotherapy. Astragalus extract boosts resistance to the immunosuppressive effects of chemotherapy drugs by encouraging macrophages to product interleukin 6 and tumour necrosis factor.
8.Antioxidant: inhibiting lipid peroxidation by 40% in vitro. These antioxidant properties may go some way to explaining the cardio- and neuro-protective effects of astragalus and astragaloside IV.
9.Cardioprotective: with studies highlighting health benefits for patients with congestive cardiac insufficiency and angina pectoris. Astragalus extracts have a cardiotonic effect.
With so many beneficial properties, particularly immunostimulant, anti-inflammatory, antioxidant and anti-glycation, Astragaloside IV is a truly essential anti-aging supplement. Its exceptional properties are due to Astragaloside IV specific ability to activate telomerase, thus slowing down the shortening of telomeres, and extending cell lifespan. Shortening of telomers is associated with cellular ageing and the development of age-related diseases.
Want to learn information about Astragaloside IV, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
2014年1月9日星期四
2014年1月8日星期三
A report on Chromic acid
A man who fell into a barrel of Chromic acid while at work Monday followed correct procedures and is recovering in a Grand Rapids, Mich., hospital, his employer said.
The man, 45, is a 10-year employee of Lacks Enterprises in Grand Rapids and was performing a maintenance function when he slipped and fell into a tank of diluted chromic acid(CAS: 7738-94-5), a toxic and carcinogenic element of the chrome-plating process, the news website MLive.com reported Monday.
It added only the man's legs were dunked in the acid.Jim Green, human resources director of the firm, said the employee was wearing a safety harness and other appropriate equipment when the accident occurred, and fellow employees hosed the victim down according to protocol.
"I spoke to him personally today, and hope to be in touch with him again soon. We anticipate a full recovery," Green said of the employee's injuries.
Chromic acid(CAS:7738-94-5)was widely used in the instrument repair industry, due to its ability to "brighten" raw brass. A chromic acid dip leaves behind a bright yellow patina on the brass. Due to growing health and environmental concerns, many have discontinued use of this chemical in their repair shops.
In this article, we can talk something about the Potential Health Effects of chromic acid.
Inhalation: Corrosive. Extremely destructive to tissues of the mucous membranes and upper respiratory tract. May cause ulceration and perforation of the nasal septum. Symptoms may include sore throat, coughing, shortness of breath, and labored breathing. May produce pulmonary sensitization or allergic asthma. Higher exposures may cause pulmonary edema.
Ingestion: Corrosive. Swallowing can cause severe burns of the mouth, throat, and stomach, leading to death. Can cause sore throat, vomiting, diarrhea. May cause violent gastroenteritis, peripheral vascular collapse, dizziness, intense thirst, muscle cramps, shock, coma, abnormal bleeding, fever, liver damage and acute renal failure.
Skin Contact: Corrosive. Symptoms of redness, pain, and severe burn can occur. Dusts and strong solutions may cause severe irritation. Contact with broken skin may cause ulcers (chrome sores) and absorption, which may cause systemic poisoning, affecting kidney and liver functions. May cause skin sensitization.
Eye Contact: Corrosive. Contact can cause blurred vision, redness, pain and severe tissue burns. May cause corneal injury or blindness.
Chromic acid Exposure: Repeated or prolonged exposure can cause ulceration and perforation of the nasal septum, respiratory irritation, liver and kidney damage and ulceration of the skin. Ulcerations at first may be painless, but may penetrate to the bone producing "chrome holes." Known to be a human carcinogen.
Aggravation of Pre-existing Conditions: Persons with pre-existing skin disorders, asthma, allergies or known sensitization to chromic acid or chromates may be more susceptible to the effects of this material.
Want to learn more information about Chromic acid, you can access the guidechem.com. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
The man, 45, is a 10-year employee of Lacks Enterprises in Grand Rapids and was performing a maintenance function when he slipped and fell into a tank of diluted chromic acid(CAS: 7738-94-5), a toxic and carcinogenic element of the chrome-plating process, the news website MLive.com reported Monday.
It added only the man's legs were dunked in the acid.Jim Green, human resources director of the firm, said the employee was wearing a safety harness and other appropriate equipment when the accident occurred, and fellow employees hosed the victim down according to protocol.
"I spoke to him personally today, and hope to be in touch with him again soon. We anticipate a full recovery," Green said of the employee's injuries.
Chromic acid(CAS:7738-94-5)was widely used in the instrument repair industry, due to its ability to "brighten" raw brass. A chromic acid dip leaves behind a bright yellow patina on the brass. Due to growing health and environmental concerns, many have discontinued use of this chemical in their repair shops.
In this article, we can talk something about the Potential Health Effects of chromic acid.
Inhalation: Corrosive. Extremely destructive to tissues of the mucous membranes and upper respiratory tract. May cause ulceration and perforation of the nasal septum. Symptoms may include sore throat, coughing, shortness of breath, and labored breathing. May produce pulmonary sensitization or allergic asthma. Higher exposures may cause pulmonary edema.
Ingestion: Corrosive. Swallowing can cause severe burns of the mouth, throat, and stomach, leading to death. Can cause sore throat, vomiting, diarrhea. May cause violent gastroenteritis, peripheral vascular collapse, dizziness, intense thirst, muscle cramps, shock, coma, abnormal bleeding, fever, liver damage and acute renal failure.
Skin Contact: Corrosive. Symptoms of redness, pain, and severe burn can occur. Dusts and strong solutions may cause severe irritation. Contact with broken skin may cause ulcers (chrome sores) and absorption, which may cause systemic poisoning, affecting kidney and liver functions. May cause skin sensitization.
Eye Contact: Corrosive. Contact can cause blurred vision, redness, pain and severe tissue burns. May cause corneal injury or blindness.
Chromic acid Exposure: Repeated or prolonged exposure can cause ulceration and perforation of the nasal septum, respiratory irritation, liver and kidney damage and ulceration of the skin. Ulcerations at first may be painless, but may penetrate to the bone producing "chrome holes." Known to be a human carcinogen.
Aggravation of Pre-existing Conditions: Persons with pre-existing skin disorders, asthma, allergies or known sensitization to chromic acid or chromates may be more susceptible to the effects of this material.
Want to learn more information about Chromic acid, you can access the guidechem.com. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
2014年1月7日星期二
New study on Diethylamine
Diethylamine is a secondary amine with the molecular structure CH3CH2NHCH2CH3 (also written as C4H11N). It is a flammable, strongly alkaline liquid. It is miscible with water and ethanol. It is a colorless liquid which often appears brown due to impurities. It is volatile and has a strong unpleasant odor, the Molecular Weight is 73.14, and CAS Registry Number is 109-89-7.
Topical diclofenac Diethylamine 1.16% gel is an NSAID that is clinically proven to be effective and well tolerated in acute and chronic musculoskeletal conditions. Applied topically, diclofenac penetrates the skin barrier to reach joints, muscles and synovial fluid. It preferentially distributes and persists in the target inflamed tissues, achieving a sufficiently high concentration to exert local therapeutic activity.
Therefore, this randomized, double-blind, placebo-controlled study aimed to assess its efficacy and safety in the treatment of acute NP. The primary objective of the study was to assess the efficacy of Diethylamine(CAS NO:109-89-7) 1.16% gel compared with placebo gel in the treatment of acute NP in terms of pain-on-movement at 48 h (Day 3) from baseline. Secondary objectives included the effect of Diethylamine 1.16% gel on pain-at-rest (PAR), functional impairment (using the neck disability index, NDI), patients’ global assessment of treatment efficacy and safety following application for 5 days.
The clinical study was designed, implemented and reported in accordance with the International Conference on Harmonization Harmonized Tripartite Guidelines for Good Clinical Practice and with the ethical principles laid down in the Declaration of Helsinki. The study protocol, protocol amendment and associated documents were reviewed by an Independent Ethics Committee in Germany. Informed consent was obtained from each subject in writing before randomization and the rights of subjects were protected.
The primary efficacy variable was POM after 48 h. Secondary efficacy variables included POM at all other visits, PAR and NDI score at Days 2, 3 and 5, response to treatment, early response to treatment, global assessment of treatment efficacy at Days 3 and 5 and use of rescue medication.
In total, 72 subjects were randomized to treatment between April 2011 and July 2011; 36 to Diethylamine 1.16% gel and 36 to placebo gel. All 72 patients completed the study and were included in the ITT population. The mean age was 33.8 years, with an almost equal number of males and females, and all subjects were Caucasian.
Overall, subjects had neck pain at baseline for about 10 days, an NDI score (24.5) midway the best and worst outcomes (0, 50), mild-to-moderate PAR (40.6 mm) and severe POM (75.5 mm). The treatment groups did not differ appreciably on any demographic or baseline neck pain characteristics. In particular, POM in the Diethylamine 1.16% gel and placebo groups were comparable at baseline (77.2 mm vs. 73.8 mm, respectively).
Want to learn more information about Diethylamine, you can access the guidechem.com.
Topical diclofenac Diethylamine 1.16% gel is an NSAID that is clinically proven to be effective and well tolerated in acute and chronic musculoskeletal conditions. Applied topically, diclofenac penetrates the skin barrier to reach joints, muscles and synovial fluid. It preferentially distributes and persists in the target inflamed tissues, achieving a sufficiently high concentration to exert local therapeutic activity.
Therefore, this randomized, double-blind, placebo-controlled study aimed to assess its efficacy and safety in the treatment of acute NP. The primary objective of the study was to assess the efficacy of Diethylamine(CAS NO:109-89-7) 1.16% gel compared with placebo gel in the treatment of acute NP in terms of pain-on-movement at 48 h (Day 3) from baseline. Secondary objectives included the effect of Diethylamine 1.16% gel on pain-at-rest (PAR), functional impairment (using the neck disability index, NDI), patients’ global assessment of treatment efficacy and safety following application for 5 days.
The clinical study was designed, implemented and reported in accordance with the International Conference on Harmonization Harmonized Tripartite Guidelines for Good Clinical Practice and with the ethical principles laid down in the Declaration of Helsinki. The study protocol, protocol amendment and associated documents were reviewed by an Independent Ethics Committee in Germany. Informed consent was obtained from each subject in writing before randomization and the rights of subjects were protected.
The primary efficacy variable was POM after 48 h. Secondary efficacy variables included POM at all other visits, PAR and NDI score at Days 2, 3 and 5, response to treatment, early response to treatment, global assessment of treatment efficacy at Days 3 and 5 and use of rescue medication.
In total, 72 subjects were randomized to treatment between April 2011 and July 2011; 36 to Diethylamine 1.16% gel and 36 to placebo gel. All 72 patients completed the study and were included in the ITT population. The mean age was 33.8 years, with an almost equal number of males and females, and all subjects were Caucasian.
Overall, subjects had neck pain at baseline for about 10 days, an NDI score (24.5) midway the best and worst outcomes (0, 50), mild-to-moderate PAR (40.6 mm) and severe POM (75.5 mm). The treatment groups did not differ appreciably on any demographic or baseline neck pain characteristics. In particular, POM in the Diethylamine 1.16% gel and placebo groups were comparable at baseline (77.2 mm vs. 73.8 mm, respectively).
Want to learn more information about Diethylamine, you can access the guidechem.com.
2014年1月6日星期一
Give you the summary of Thiophene-2-ethylamine
Basic information:
IUPAC Name: 2-thiophen-2-ylethanamine
Empirical Formula: C6H9NS
Molecular Weight: 127.2074
Index of Refraction: 1.567
Molar Refractivity: 37.72 cm3
Molar Volume: 115.4 cm3
Surface Tension: 43.3 dyne/cm
Density: 1.102 g/cm3
Flash Point: 74.6 C
Enthalpy of Vaporization: 43.59 kJ/mol
Boiling Point: 199.7 C at 760 mmHg
Vapour Pressure: 0.337 mmHg at 25C
Storage temp: Refrigerator (+4 C)
Sensitive: Air Sensitive
Appearance: colorless to yellow liquid
EINECS:250-196-9
CAS Registry Number:30433-91-1
Usages of Thiophene-2-ethylamine:
Thiophene-2-ethylamine is lipid-lowering drugs, platelet aggregation inhibitors, cardiovascular vasodilators, 5-lipoxygenase inhibitors and a variety of antimicrobial drugs and other biologically active drug intermediates, mainly used for the synthesis of cardiovascular and cerebrovascular disease drugs ticlopidine hydrochloride. As downstream drug development, this compound paid more attention to the fine chemical intermediates.
In commercial Thiophene-2-ethylamine(CAS NO:30433-91-1) can be prepared by the reaction of butane and sulfur. Thiophenes are also prepared by the reaction of diketones with Lawesson's reagent. This compoud and its derivatives exist in petroleum or coal. It is used as a solvent and chemical intermediate. Its derivatives are used in manufacturing dyes, aroma compounds and pharmaceuticals. Thiophene-2-ethylamine is used as an intermediate to manufacture pharmaceuticals such as antiplatelet drug (Clopidogrel, Ticlopidine) used to lessen the chance of heart attack or stroke.
MSDS of Thiophene-2-ethylamine
1.Potential Health Effects
Eye: Causes eye irritation. May cause chemical conjunctivitis.
Skin: Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Can produce delayed pulmonary edema.
Chronic: No information found.
2.First Aid Measures
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Supply information in guidechem
1.AOPHARM
Thiophene-2-ethylamine
Updatetime:Jan 06 2014
Purity:99%
DetailDesc:Pale yellow clear liquid, long buy become red
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd.
2.Capot Chemical Co., Ltd.
Thiophene-2-ethylamine
Updatetime:Dec 31 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:127.21,C6H9NS
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road
Want to learn more information about Thiophene-2-ethylamine, you can access the guidechem.com.Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
IUPAC Name: 2-thiophen-2-ylethanamine
Empirical Formula: C6H9NS
Molecular Weight: 127.2074
Index of Refraction: 1.567
Molar Refractivity: 37.72 cm3
Molar Volume: 115.4 cm3
Surface Tension: 43.3 dyne/cm
Density: 1.102 g/cm3
Flash Point: 74.6 C
Enthalpy of Vaporization: 43.59 kJ/mol
Boiling Point: 199.7 C at 760 mmHg
Vapour Pressure: 0.337 mmHg at 25C
Storage temp: Refrigerator (+4 C)
Sensitive: Air Sensitive
Appearance: colorless to yellow liquid
EINECS:250-196-9
CAS Registry Number:30433-91-1
Usages of Thiophene-2-ethylamine:
Thiophene-2-ethylamine is lipid-lowering drugs, platelet aggregation inhibitors, cardiovascular vasodilators, 5-lipoxygenase inhibitors and a variety of antimicrobial drugs and other biologically active drug intermediates, mainly used for the synthesis of cardiovascular and cerebrovascular disease drugs ticlopidine hydrochloride. As downstream drug development, this compound paid more attention to the fine chemical intermediates.
In commercial Thiophene-2-ethylamine(CAS NO:30433-91-1) can be prepared by the reaction of butane and sulfur. Thiophenes are also prepared by the reaction of diketones with Lawesson's reagent. This compoud and its derivatives exist in petroleum or coal. It is used as a solvent and chemical intermediate. Its derivatives are used in manufacturing dyes, aroma compounds and pharmaceuticals. Thiophene-2-ethylamine is used as an intermediate to manufacture pharmaceuticals such as antiplatelet drug (Clopidogrel, Ticlopidine) used to lessen the chance of heart attack or stroke.
MSDS of Thiophene-2-ethylamine
1.Potential Health Effects
Eye: Causes eye irritation. May cause chemical conjunctivitis.
Skin: Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Can produce delayed pulmonary edema.
Chronic: No information found.
2.First Aid Measures
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Supply information in guidechem
1.AOPHARM
Thiophene-2-ethylamine
Updatetime:Jan 06 2014
Purity:99%
DetailDesc:Pale yellow clear liquid, long buy become red
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd.
2.Capot Chemical Co., Ltd.
Thiophene-2-ethylamine
Updatetime:Dec 31 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:127.21,C6H9NS
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road
Want to learn more information about Thiophene-2-ethylamine, you can access the guidechem.com.Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
2014年1月5日星期日
The recent development in the field of ranolazine
Molecular Formula:C24H33N3O4
Molecular Weight: 427.54
Density:1.174 g/cm3
Boiling Point:624.1 C at 760 mmHg
Flash Point:331.2 C
Appearance: white solid
CAS Registry Number:95635-55-5
Usage: Anti-ischemic agent which modulates myocardial metabolism.
Ranolazine is used alone or with other medications to treat ongoing angina (chest pain or pressure that is felt when the heart does not get enough oxygen). Ranolazine is in a class of medications called anti-anginals. The exact way that ranolazine works is not known at this time.
Ranolazine(CAS NO: 95635-55-5) is a medication that belongs to the drug class known as cardiovascular agents. Ranexa is prescribed for the treatment of chronic angina. Common side effects of Ranexa include dizziness, nausea, constipation, headache, swelling in hands, ankles, or feet, slow, fast, or irregular heartbeats, tremors, blood in the urine and shortness of breath.
This is the recent development in the field of ranolazine. This study was done in 6560 post-ACS NSTEMI patients followed up for one year. Although ranolazine did not show significant benefit in the study's primary endpoints of cardiovascular death, myocardial infarction, or recurrent ischemia; it exhibited a potential benefit in arrhythmia.
Earlier, ranolazine increasing QT interval (about 2 to 6 ms) was of concern, which has a theoretical risk of causing arrhythmia. Findings of MERLIN TIMI 36 should mitigate this concern. However, studies specifically designed to evaluate the potential role of ranolazine as an antiarrhythmic agent are warranted.
Based on encouraging safety data shown in MERLIN TIMI 36 trial, CV Therapeutics has applied to the US FDA for first-line angina indication. It has also applied to the U.S. Food and Drug Administration (FDA) for two more indications, such as HbA1c reduction in coronary artery disease patients with diabetes and antiarrhythmic benefits. Based on initial evaluation of data presented, the FDA has accepted the application and has set the action date as 27 July 2008.
Among patients with ACS, ranolazine, an inhibitor of late INa, has antiarrhythmic effects as assessed by Holter monitoring. In particular, patients treated with ranolazine had fewer episodes of VT > 8 beats, SVT, and ventricular pauses > 3 seconds. Ranolazine was associated with a 37% reduction in risk of VT lasting >= 8 beats. Reduction in VT >= 8 beats was significant and consistent in high-risk subgroups based on ejection fraction, corrected QT interval, TIMI risk score, history of heart failure, and the presence or absence of ischemia on ECG.
Want to learn more information about Ranolazine, you can access the guidechem.com. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
Molecular Weight: 427.54
Density:1.174 g/cm3
Boiling Point:624.1 C at 760 mmHg
Flash Point:331.2 C
Appearance: white solid
CAS Registry Number:95635-55-5
Usage: Anti-ischemic agent which modulates myocardial metabolism.
Ranolazine is used alone or with other medications to treat ongoing angina (chest pain or pressure that is felt when the heart does not get enough oxygen). Ranolazine is in a class of medications called anti-anginals. The exact way that ranolazine works is not known at this time.
Ranolazine(CAS NO: 95635-55-5) is a medication that belongs to the drug class known as cardiovascular agents. Ranexa is prescribed for the treatment of chronic angina. Common side effects of Ranexa include dizziness, nausea, constipation, headache, swelling in hands, ankles, or feet, slow, fast, or irregular heartbeats, tremors, blood in the urine and shortness of breath.
This is the recent development in the field of ranolazine. This study was done in 6560 post-ACS NSTEMI patients followed up for one year. Although ranolazine did not show significant benefit in the study's primary endpoints of cardiovascular death, myocardial infarction, or recurrent ischemia; it exhibited a potential benefit in arrhythmia.
Earlier, ranolazine increasing QT interval (about 2 to 6 ms) was of concern, which has a theoretical risk of causing arrhythmia. Findings of MERLIN TIMI 36 should mitigate this concern. However, studies specifically designed to evaluate the potential role of ranolazine as an antiarrhythmic agent are warranted.
Based on encouraging safety data shown in MERLIN TIMI 36 trial, CV Therapeutics has applied to the US FDA for first-line angina indication. It has also applied to the U.S. Food and Drug Administration (FDA) for two more indications, such as HbA1c reduction in coronary artery disease patients with diabetes and antiarrhythmic benefits. Based on initial evaluation of data presented, the FDA has accepted the application and has set the action date as 27 July 2008.
Among patients with ACS, ranolazine, an inhibitor of late INa, has antiarrhythmic effects as assessed by Holter monitoring. In particular, patients treated with ranolazine had fewer episodes of VT > 8 beats, SVT, and ventricular pauses > 3 seconds. Ranolazine was associated with a 37% reduction in risk of VT lasting >= 8 beats. Reduction in VT >= 8 beats was significant and consistent in high-risk subgroups based on ejection fraction, corrected QT interval, TIMI risk score, history of heart failure, and the presence or absence of ischemia on ECG.
Want to learn more information about Ranolazine, you can access the guidechem.com. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
2014年1月2日星期四
Who can supply high quality 2-Bromo-3-hydroxypyridine?
2-Bromo-3-hydroxypyridine is also known as 2-Bromo-3-pyridinol. It belongs to the product categories of Blocks; Bromides; Pyridines; Pyridine; Pyridine Series; Pyridines, Pyrimidines, Purines and Pteredines; Its EINECS number is 207-857-1. This chemical's molecular formula is C5H4BrNO and molecular weight is 174.00, CAS NO is 6602-32-0.
What's more, its systematic name is 2-bromopyridin-3-ol. It should be sealed and stored in a cool and dry place. Moreover, it should be protected from light. It is used in organic synthesis. Itcan be used to produce 2-bromo-3-isopropoxypyridine at the temperature of 80 C. It will need reagent K2CO3 and solvent dimethylformamide with the reaction time of 2 hours. The yield is about 99%.
Here are some hot suppliers of 2-Bromo-3-hydroxypyridine(CAS NO:6602-32-0) in guidechem, if you need this chemical,you can contact them, I will show you the phone number and addresss of the suppliers.
1.AOPHARM
Updatetime:Jan 02 2014
Purity:99%
DetailDesc:White crystal
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd.
2.Hangzhou Dayangchem Co., Ltd.
Updatetime:Jan 02 2014
DetailDesc:2-Bromo-3-hydroxypyridine
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328 WenEr Rd. Hangzhou City 310012 China
3.Capot Chemical Co., Ltd.
Updatetime:Dec 31 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:174.00,C5H4BrNO
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road
4.Shanghai Dell Chemical Co.Ltd
Updatetime:Dec 30 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai
5.Jinan Haohua Industry Co., Ltd.
Updatetime:Jan 02 2014
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Haohua Industry has set up four big production bases and one R&D Center in China. Over the past years, we are engaged in the exporting business, our products have reached far to the USA, Europe, South Asia, Middle East and so on.
Tel:0086-531-58773055
Address:No.59 Gongye South RD
6.HEBEI CUI FENG IMPORT&EXPORT TRADE CO.,LTD
2-Bromo-3-hydroxypyridine
Updatetime:Jan 02 2014
Supply Ability:Success
DetailDesc:2-Bromo-3-hydroxypyridine
Tel:86-311-80955068
Address:No 98 Gongnong Street,Shijiazhuang Hebei,China
7.China Huanyu Chemical Industrial Co.,Ltd
2-Bromo-3-hydroxypyridine
Updatetime:Dec 31 2013
DetailDesc:2-Bromo-3-hydroxypyridine
Tel:86-310-6034055
Address:Maoyi Road,Hanshan District,Handan
8.Shanghai UCHEM Inc.
2-Bromo-3-hydroxypyridine
Updatetime:Dec 30 2013
DetailDesc:2-Bromo-3-hydroxypyridine
Tel:086-021-61555264
Address:4th Floor,Build A,500Jianyun Road,Zhoupu,Pudong,Shanghai
9.Nanjing Chemlin Chemical Co., Ltd.
2-bromo-3-hydroxypyridine
Updatetime:Dec 31 2013
Purity:97.00%
DetailDesc:intermediates, drug discovery
Tel:86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Want to find more supply information about 2-Bromo-3-hydroxypyridine or any other chemicals, you can access the guidechem.com. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
What's more, its systematic name is 2-bromopyridin-3-ol. It should be sealed and stored in a cool and dry place. Moreover, it should be protected from light. It is used in organic synthesis. Itcan be used to produce 2-bromo-3-isopropoxypyridine at the temperature of 80 C. It will need reagent K2CO3 and solvent dimethylformamide with the reaction time of 2 hours. The yield is about 99%.
Here are some hot suppliers of 2-Bromo-3-hydroxypyridine(CAS NO:6602-32-0) in guidechem, if you need this chemical,you can contact them, I will show you the phone number and addresss of the suppliers.
1.AOPHARM
Updatetime:Jan 02 2014
Purity:99%
DetailDesc:White crystal
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd.
2.Hangzhou Dayangchem Co., Ltd.
Updatetime:Jan 02 2014
DetailDesc:2-Bromo-3-hydroxypyridine
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328 WenEr Rd. Hangzhou City 310012 China
3.Capot Chemical Co., Ltd.
Updatetime:Dec 31 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:174.00,C5H4BrNO
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road
4.Shanghai Dell Chemical Co.Ltd
Updatetime:Dec 30 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai
5.Jinan Haohua Industry Co., Ltd.
Updatetime:Jan 02 2014
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Haohua Industry has set up four big production bases and one R&D Center in China. Over the past years, we are engaged in the exporting business, our products have reached far to the USA, Europe, South Asia, Middle East and so on.
Tel:0086-531-58773055
Address:No.59 Gongye South RD
6.HEBEI CUI FENG IMPORT&EXPORT TRADE CO.,LTD
2-Bromo-3-hydroxypyridine
Updatetime:Jan 02 2014
Supply Ability:Success
DetailDesc:2-Bromo-3-hydroxypyridine
Tel:86-311-80955068
Address:No 98 Gongnong Street,Shijiazhuang Hebei,China
7.China Huanyu Chemical Industrial Co.,Ltd
2-Bromo-3-hydroxypyridine
Updatetime:Dec 31 2013
DetailDesc:2-Bromo-3-hydroxypyridine
Tel:86-310-6034055
Address:Maoyi Road,Hanshan District,Handan
8.Shanghai UCHEM Inc.
2-Bromo-3-hydroxypyridine
Updatetime:Dec 30 2013
DetailDesc:2-Bromo-3-hydroxypyridine
Tel:086-021-61555264
Address:4th Floor,Build A,500Jianyun Road,Zhoupu,Pudong,Shanghai
9.Nanjing Chemlin Chemical Co., Ltd.
2-bromo-3-hydroxypyridine
Updatetime:Dec 31 2013
Purity:97.00%
DetailDesc:intermediates, drug discovery
Tel:86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Want to find more supply information about 2-Bromo-3-hydroxypyridine or any other chemicals, you can access the guidechem.com. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
2014年1月1日星期三
Chinese m-Fluoroanisole Industry
Chapter one: the Overview of China’s m-Fluoroanisole Industry
1.The Definition and Features of m-Fluoroanisole Products
2.Analysis of the Macro-Environment Affecting China’s m-Fluoroanisole Industry
3.The effect social culture having on m-Fluoroanisole industry
4.The effect macro-environment development having on the m-Fluoroanisole industry
5.The effect technology factors having on m-Fluoroanisole industry
6.The effect national policies having on m-Fluoroanisole industry
Chapter two: The Supply Analysis of m-Fluoroanisole(CAS NO:456-49-5) Industry
1.the regional analysis of China’s m-Fluoroanisole manufactures
2.the regional analysis of China’s m-Fluoroanisole output
3.statistical analysis of the output of China’s m-Fluoroanisole industry 2006-2009
Chapter three: The Demand Analysis of m-Fluoroanisole Industry
1.the statistical analysis of China’s m-Fluoroanisole industry 2006-2009
2.the demand analysis of China’s m-Fluoroanisole regional market
Chapter four: The Overall Development Situation of m-Fluoroanisole(CAS NO:456-49-5) Industry
1.analysis of the lifecycle in m-Fluoroanisole industry
2.analysis of the enterprise quality and scale in m-Fluoroanisole industry
3.analysis of the market regional features
4.the processing innovation and technology revolution
5.the market capacity and growth speed of m-Fluoroanisole 2006-2009
Chapter five: The Competition Structure Analysis of m-Fluoroanisole Industry
1.threat from the potential entrants
2.threat from substitute good
3.the theory basis of industrial competition analysis
4.the competition structure analysis of m-Fluoroanisole industry
5.analysis of industrial competition group
6.competition advantage analysis of key enterprises
7.price competitiveness
Chapter six: The Market Channel Analysis of m-Fluoroanisole Industry
1.sales channel analysis of key enterprises
2.situation analysis of main agents in each regional market
3.analysis of the sales channel forms
4.comparison of sales channel factors
Chapter seven: Factors Influencing China’s m-Fluoroanisole Industry Market Development 2010-2013
1.analysis of the effect from subprime financial crisis
2.favorable factors
3.adverse factors
4.policy factors
Chapter eight: The Industrial Chain Analysis of m-Fluoroanisole Industry
1.analysis of the China’s upstream m-Fluoroanisole industry
2.analysis of the China’s downstream m-Fluoroanisole industry
3.the constitution of m-Fluoroanisole industrial chain
Chapter nine: Profitability Analysis of m-Fluoroanisole Industry
1.analysis of gross profit from sales in m-Fluoroanisole industry 2006-2009
2.analysis of the industry rate of return on net sales 2006-2009
3.analysis of the rate of return on total assets 2006-2009
4.analysis of the rate of the return on net assets 2006-2009
5.analysis of the industry ratio of profit and tax to output value 2006-2009
6.the total profit analysis of m-Fluoroanisole industry 2006-2009
7.the total profit analysis of m-Fluoroanisole industry 2006-2009
8.the total profit comparison of different size m-Fluoroanisole industry 2006-2009
9.the total profit comparison of different ownership m-Fluoroanisole industry 2006-2009
Chapter ten: Analysis of International Market in m-Fluoroanisole Industry
1.analysis of international market in m-Fluoroanisole industry
2.analysis of import and export situation of m-Fluoroanisole products
3.the ways China’s m-Fluoroanisole enterprises entering into international market
Want to learn more information about m-Fluoroanisole, you can access the guidechem.com.
1.The Definition and Features of m-Fluoroanisole Products
2.Analysis of the Macro-Environment Affecting China’s m-Fluoroanisole Industry
3.The effect social culture having on m-Fluoroanisole industry
4.The effect macro-environment development having on the m-Fluoroanisole industry
5.The effect technology factors having on m-Fluoroanisole industry
6.The effect national policies having on m-Fluoroanisole industry
Chapter two: The Supply Analysis of m-Fluoroanisole(CAS NO:456-49-5) Industry
1.the regional analysis of China’s m-Fluoroanisole manufactures
2.the regional analysis of China’s m-Fluoroanisole output
3.statistical analysis of the output of China’s m-Fluoroanisole industry 2006-2009
Chapter three: The Demand Analysis of m-Fluoroanisole Industry
1.the statistical analysis of China’s m-Fluoroanisole industry 2006-2009
2.the demand analysis of China’s m-Fluoroanisole regional market
Chapter four: The Overall Development Situation of m-Fluoroanisole(CAS NO:456-49-5) Industry
1.analysis of the lifecycle in m-Fluoroanisole industry
2.analysis of the enterprise quality and scale in m-Fluoroanisole industry
3.analysis of the market regional features
4.the processing innovation and technology revolution
5.the market capacity and growth speed of m-Fluoroanisole 2006-2009
Chapter five: The Competition Structure Analysis of m-Fluoroanisole Industry
1.threat from the potential entrants
2.threat from substitute good
3.the theory basis of industrial competition analysis
4.the competition structure analysis of m-Fluoroanisole industry
5.analysis of industrial competition group
6.competition advantage analysis of key enterprises
7.price competitiveness
Chapter six: The Market Channel Analysis of m-Fluoroanisole Industry
1.sales channel analysis of key enterprises
2.situation analysis of main agents in each regional market
3.analysis of the sales channel forms
4.comparison of sales channel factors
Chapter seven: Factors Influencing China’s m-Fluoroanisole Industry Market Development 2010-2013
1.analysis of the effect from subprime financial crisis
2.favorable factors
3.adverse factors
4.policy factors
Chapter eight: The Industrial Chain Analysis of m-Fluoroanisole Industry
1.analysis of the China’s upstream m-Fluoroanisole industry
2.analysis of the China’s downstream m-Fluoroanisole industry
3.the constitution of m-Fluoroanisole industrial chain
Chapter nine: Profitability Analysis of m-Fluoroanisole Industry
1.analysis of gross profit from sales in m-Fluoroanisole industry 2006-2009
2.analysis of the industry rate of return on net sales 2006-2009
3.analysis of the rate of return on total assets 2006-2009
4.analysis of the rate of the return on net assets 2006-2009
5.analysis of the industry ratio of profit and tax to output value 2006-2009
6.the total profit analysis of m-Fluoroanisole industry 2006-2009
7.the total profit analysis of m-Fluoroanisole industry 2006-2009
8.the total profit comparison of different size m-Fluoroanisole industry 2006-2009
9.the total profit comparison of different ownership m-Fluoroanisole industry 2006-2009
Chapter ten: Analysis of International Market in m-Fluoroanisole Industry
1.analysis of international market in m-Fluoroanisole industry
2.analysis of import and export situation of m-Fluoroanisole products
3.the ways China’s m-Fluoroanisole enterprises entering into international market
Want to learn more information about m-Fluoroanisole, you can access the guidechem.com.
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