2013年9月1日星期日

Ceftriaxone disodium salt hemiheptahydrate for Injection


Ceftriaxone disodium salt hemiheptahydrate is a third-generation cephalosporin. Against Enterobacteriaceae have strong activity. Against Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter fluorine labor, indole-positive Proteus, and Serratia spp Prussian Vuitton, the MIC90 is from 0.12 to 0.25mg. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa are poor sensitivity to Ceftriaxone disodium salt hemiheptahydrate.

Ceftriaxone disodium salthemiheptahydrate has a strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitides. On the hemolytic streptococcus and pneumococcus Ceftriaxone disodium salt hemiheptahydrate also has a good effect. Against Staphylococcus aureus, MIC is 2 to 4mg / L. Methicillin-resistant staphylococci and enterococci resistant to Ceftriaxone disodium salt hemiheptahydrate. Most of Bacteroides fragilis resistant to Ceftriaxone disodium salt hemiheptahydrate.

Ceftriaxone disodium salt hemiheptahydrate used for curing lower respiratory tract infections, urinary tract, biliary tract infections, and intra-abdominal infections, pelvic infections, skin and soft tissue infections, bone and joint infections, septicemia, meningitis, and operative infection, which is caused sensitive bacteria. This product is simply a single dose to treat gonorrhea.

The adverse reactions of Ceftriaxone disodium salt hemiheptahydrate are related to dose and treatment. Local reactions have phlebitis (1.86%), in addition may have a rash, itching, fever, bronchospasm, and serum sickness and other allergic reactions (2.77%), headache or dizziness (0.27%), diarrhea, nausea, vomiting, abdominal pain, colitis, jaundice, flatulence, taste disturbance, indigestion and other gastrointestinal reactions (3.45%). Laboratory abnormalities are about 19%, of which 14% hematological abnormalities, including increased eosinophils, platelets increase or decrease and leukopenia. Liver and kidney dysfunction was 5% and 1.4%.

For pregnant and lactating women, although the application of cephalosporins in question has not been reported, its application must still weigh. The drug safety of Newborns (birth weight less than 2kg) has not been established. Jaundice of the newborn or neonatal jaundice serious tendency should be used with caution or avoid Ceftriaxone disodium salt hemiheptahydrate. Unless elderly patients weakness, malnutrition or severe renal impairment, the elderly applications generally do not need to adjust the dose of Ceftriaxone disodium salt hemiheptahydrate.


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