Mifepristone is a synthetic steroid compound used as a pharmaceutical. It is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. Mifepristone is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing's Syndrome (due to ectopic/neoplastic ACTH/Cortisol secretion).
During early trials, it was known as RU-38486 or simply RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed—often amid controversy. It is marketed under tradenames Korlym and Mifeprex, according to FDA Orange Book. Some examples of such drugs include ibuprofen, aspirin, and naproxen. This medication is often used for people that are at an especially high risk of experiencing ulcers.
The Primary Use
Misoprostol(CAS NO.:84371-65-3) is a medication that works to stop stomach ulcers from happening when individuals take NSAIDs. It reduces the chances of severe complications of ulcers, like bleeding. It functions by defending the lining of the stomach by reducing the levels of acid that come into contact with the lining.
Used as Abortion
A secondary use for this medication is for the termination of pregnancy, which is also known as abortion.An abortion is the termination of a pregnancy. Whenever possible, abortions should be performed by the ninth week of pregnancy in order to limit complications. There are risks involved at any time---during the procedure and afterward. Choosing abortion requires careful consideration. It is used alongside another drug, which is known as mifepristone, in order to end a pregnancy. Mifeprostone obstructs progesterone, which is a hormone that is necessary to keep a pregnancy going. This results in the shedding of the uterine lining, and the softening of the cervix, which could lead to bleeding. Then, misoprostol is administered, which causes the uterus to contract and causes the pregnancy to terminate itself within approximately 6 to 8 hours.
Help with Childbirth
Mifeprostone is also sometimes used in helping with childbirth, when the baby is being delivered. It can assist in inducing labor as well as cervical ripening. It also can help treat and manage serious bleeding that sometimes happens right about delivery. It is administered vaginally in those situations, and functions by enabling the muscles of the womb to contract.
Common Side Effects
In using Mifeprostone, it is possible to experience several common side effects. These common side effects include stomach cramps, diarrhea, and nausea. These side effects are considered to be minor, because they usually rapidly subside (as the body adapts to the medicine). However, if you experience any of these side effects, and they intensify with time (as opposed to decreasing), talk with your doctor about them as soon as possible.
Severe Side Effects
Using Mifeprostone also could lead to some very uncommon, but simultaneously very severe side effects as well. If you have any of these side effects, you need to seek emergency medical attention (as they could result in potentially harmful consequences). These side effects are heavy or abnormal vaginal bleeding, and menstrual irregularities or problems.
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Mifepristone (formerly known as RU-486) is a medication that blocks the action of the hormone progesterone. Progesterone is needed to sustain a pregnancy. Mifepristone has been used, in combination with other medications called prostaglandins, for medical abortion since 1988 in France and China, and since the early 1990's in the United Kingdom and Sweden. It has been licensed for use in 37 countries including the United States where it was approved in September 2000. Millions of women worldwide have safely used mifepristone regimens to end their pregnancies.
Mifepristone(CAS NO.: 84371-65-3) is used alone or in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 49 days or less since your last menstrual period began. Mifepristone is in a class of medications called antiprogestational steroids. It works by blocking the activity of progesterone, a substance your body makes to help continue pregnancy.
Mifepristone comes as a tablet to take by mouth. It should be taken only in a clinic, medical office, or hospital under the supervision of a qualified doctor. You will take three tablets of mifepristone at one time on the first day. Two days later you must go back to your doctor. If your doctor is not certain that your pregnancy has ended, you will take two tablets of another medication called misoprostol. You may have vaginal bleeding for 9 to 30 days or longer. Fourteen days after taking mifepristone, you must go back to your doctor for an exam or ultrasound to make sure that the pregnancy has ended. Take mifepristone exactly as directed.
Mifepristone is also sometimes used to end pregnancies when more than 49 days have passed since the woman's last menstrual period; as an emergency contraceptive after unprotected sexual intercourse ('morning-after pill'); to treat tumors of the brain, endometriosis (growth of uterus tissue outside the uterus), or fibroids (noncancerous tumors in the uterus); or to induce labor (to help start the birth process in a pregnant woman). Talk to your doctor about the possible risks of using this drug for your condition.
Mifepristone also has some side effects on our health. Side effects, such as pain, cramping and vaginal bleeding, result from the abortion process itself, and are therefore expected with a medical abortion. Other side effects may include nausea, vomiting, diarrhea, chills, or fever. Complications are rare, but may include infection, excessive vaginal bleeding requiring transfusion (occurs in approximately 1 in 500 cases), incomplete abortion or ongoing pregnancy which requires a suction abortion (see above). In exceedingly rare instances, as with miscarriage, suction abortion and childbirth, death may occur. Reports of death after medical abortion are very rare - less than 1 in 100,000 cases - a rate comparable to that for early surgical abortion and for miscarriage.
Mifepristone is available only from your doctor. It is stored at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
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