Something important before taking Alendronate sodium

Alendronate sodium is a bisphosphonate drug used for osteoporosis and several other bone diseases. It is marketed alone as well as in combination with vitamin D. Alendronate sodium is a white Crystalline Solid, the Molecular Formula is C4H12NNaO7P2.3(H2O), Molecular Weight is 249.096042, and the CAS Registry Number is 121268-17-5.

Available by prescription only, alendronate sodium is an oral medication used for treating osteoporosis and Paget's disease of the bone. In postmenopausal women, the medication is also approved to prevent osteoporosis. The tablets come in five strengths and belong to a class of drugs known as bisphosphonates.

The medication works by slowing down the rate at which bone is broken down and encouraging normal reformation. Depending on your dose, the tablets can be taken daily or weekly. For people who are unable to take tablets, a liquid form of alendronate sodium is available.

Alendronate sodium is a medicine that can help to strengthen the bones in a body. It has Vitamin D that absorbs calcium, which is needed to make bones strong. It is most commonly taken by men and women who suffer from osteoporosis. This medicine is sometimes used to fight Paget's disease, which is a bone disease.

But there are something important you should know, while you are taking Alendronate sodium

1.Things you must do

If you develop difficulty or pain upon swallowing, chest pain, or new or worsening heartburn, stop taking Alendronate sodium and call your doctor. If you become pregnant while taking this medicine, stop taking the tablets and tell your doctor. If you are about to be started on any new medicine, tell your doctor and pharmacist that you are taking this medicine.If you require a dental procedure, tell your dentist that you are taking this medicine. If you develop new or unusual pain in your hip or thigh, tell your doctor.

Rarely, patients have experienced fracture in a specific part of the thigh bone.If you break a bone (have a fracture), tell your doctor that you are taking  Alendronate sodium. Make sure you have an adequate intake of calcium in your diet. Your doctor, dietician or pharmacist can tell you what foods you should eat.

2.Things you must not do

Do not give your medicine to anyone else, even if they have the same condition as you. Do not take Alendronate sodium to treat any other complaint unless your doctor tells you to.

3.Things that would be helpful for your osteoporosis

Some self help measures suggested below may help your osteoporosis, while you need to take Alendronate sodium. Talk to your doctor or pharmacist about these measures and for more information. Exercise can be helpful in building and maintaining strong bones. Regular exercise such as a brisk walk is a good idea. Talk to your doctor before you begin any exercise program.

Eat a balanced diet. You may need to increase the amount of calcium in your diet by eating calcium-rich foods or taking a calcium supplement. Your doctor will advise you.

Smoking appears to increase the rate at which you lose bone, therefore, may increase your risk of fracture. Your doctor may ask you to stop smoking or at least cut down, while you need to take Alendronate sodium.

Your doctor may advise you to cut down the amount of alcohol you drink, while you need to take Alendronate sodium. If you drink excessively on a regular basis, you may increase your risk of developing osteoporosis.

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What is Alendronate sodium used for?

Alendronate sodium is chemically described as (4-amino-1-hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate. The empirical formula of alendronate sodium is C4H12NNaO7P2•3H2O, its formula weight is 325.12 and CAS NO. is121268-17-5. 

Alendronate sodium is a white, crystalline, nonhygroscopic powder. It is soluble in water, very slightly soluble in alcohol, and practically insoluble in chloroform. Alendronate sodium is an important medicine, it is used widely in medical community, so let talk about what Alendronate sodium treats for?

1. Treatment and prevention of osteoporosis in postmenopausal women. 

For the treatment of osteoporosis, alendronate sodium increases bone mass and reduces the incidence of fractures, including those of the hip and spine (vertebral compression fractures). Osteoporosis may be confirmed by the finding of low bone mass (for example, at least 2 standard deviations below the premenopausal mean) or by the presence or history of osteoporotic fracture. (See CLINICAL PHARMACOLOGY, Pharmacodynamics.) 

For the prevention of osteoporosis, alendronate sodium may be considered in postmenopausal women who are at risk of developing osteoporosis and for whom the desired clinical outcome is to maintain bone mass and to reduce the risk of future fracture. Bone loss is particularly rapid in postmenopausal women younger than age 60. Risk factors often associated with the development of postmenopausal osteoporosis include early menopause; moderately low bone mass (for example, at least 1 standard deviation below the mean for healthy young adult women); thin body build; Caucasian or Asian race; and family history of osteoporosis. The presence of such risk factors may be important when considering the use of alendronate sodium for prevention of osteoporosis. 

2. Treatment to increase bone mass in men with osteoporosis. 

Treatment of glucocorticoid-induced osteoporosis in men and women receiving glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who have low bone mineral density (see PRECAUTIONS, Glucocorticoid-Induced Osteoporosis ). Patients treated with glucocorticoids should receive adequate amounts of calcium and vitamin D. 

3. Treatment of Paget's disease of bone in men and women. 

Treatment of Alendronate sodium is indicated in patients with Paget's disease of bone having alkaline phosphatase at least 2 times the upper limit of normal, or those who are symptomatic, or those at risk for future complications from their disease. 


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