Discussions about 2-Ethyl-1-hexanol

2-Ethyl-1-hexanol is a branched, eight-carbon alcohol. After the lighter alcohols (those with one to four carbons such as methanol or butanol), 2-Ethyl-1-hexanol is the mosit important synthetic alcohol. Industrially, 2-Ethyl-1-hexanol is mainly used in the manufacture of ester plasticizers which are used in producing soft polyvinyl chloride. 

Almost all 2-Ethyl-1-hexano(CAS NO:104-76-7) is converted into the diesters bis(2-ethylhexyl) phthalate (DEHP), a plasticizer. Because it is a fatty alcohol, its esters tend to have emollient properties. For example, the sunscreen octocrylene contains a the chemical for this purpose. It is also commonly used as a low volatility solvent. It can also be used as an octane booster when reacted with nitric acid.

The other major use of 2-Ethyl-1-hexanol(CAS NO:104-76-7) is in the manufacture of a chemical used in the manufacture of coating materials, adhesives, printing inks, and impregnating agents. EPA expects that exposure to 2-Ethyl-1-hexanol is widespread, though not at high concentrations. It occurs naturally in food and is used as a flavor volatile and is approved as an indirect U.S. Food and Drug Administration (FDA.) Food Additive. In addition, It is used as a pesticide inert ingredient in pesticide formulations applied to growing crops, raw agricultural commodities (RAGs), or animals. As such, it has three tolerance exemptions: 40.Q.EB 180.910; 40.Q.EB 180.920; and 40 .Q.EB 180.930. 

Individuals may be exposed to 2-Ethyl-1-hexanol through the oral, dermal, and inhalation routes of exposure. In terms of a pesticide inert ingredient, EPA expects that exposure to 2-Ethyl-1-hexanol would primarily be through the oral route, via consumption of agricultural crops to which this inert ingredient has been applied as a solvent, cosolvent, or defoamer and exposure through drinking water. Additional dermal and inhalation exposure may occur from residential use of pesticide products containing 2-Ethyl-1-hexanol on ornamental plants and lawns, as well as from the use in and around the home and on textiles. EPA expects that exposure to 2-Ethyl-1-hexanol will be low, both through food (which includes drinking water) and residential exposure.

Overall, 2-Ethyl-1-hexanol is of low acute toxicity by the oral and dermallroutes; however, it is moderately irritating to the skin and severely irritating to the eye. In subchronic repeat dose studies, hepatic effects were noted, including increased liver weights and peroxisome proliferation in rats and mice. To explore this finding alnd EPA's concern that it could induce cancer, EPA required oncogenicity testing under the Toxic Substances Control Act. After reviewing the studies submitted under the test rule, the Agency concluded that 2-Ethyl-1-hexanol is not carcinogenic in the mouse or rat. No evidence of neurotoxicity was identified. The available data indicate that 2-Ethyl-1-hexanol is not mutagenic.

Further, the available data show that 2-Ethyl-1-hexanol is not developmentally toxic. Because exposure to 2-Ethyl-1-hexanol is expected to be low and developmental toxicity is not expected, a safety factor analysis was not used to assess the risks resulting from the use of 2-Ethyl-1-hexanol.

Taking into consideration all available information on 2-Ethyl-1-hexanol, EPA has determined that there is a reasonable certainty that no harm to any population subgroup will result from aggregate exposure to 2-Ethyl-1-hexanol used as an inert ingredient in pesticide products when considering dietary exposure and all other nonoccupational sources of pesticide exposure for which there is reliable information. 

Overall exposure due to the inert use of 2-Ethyl-1-hexanol is expected to result in human exposure below any dose level that would produce any adverse effect. Therefore, it is recommended that the three exemptions from the requirement of a tolerance established for residues of 2-Ethyl-1-hexanol can be considered reassessed as safe under section 408(q) of FFDCA.

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