The Arterial Function of Isoflavone

Isoflavones are a class of phytoestrogens plant-derived compounds with estrogenic activity. Soybeans and soy products are the richest sources of isoflavones in the human diet.

Isoflavone(CAS NO: 574-12-9) is used for high cholesterol, high blood pressure, and preventing diseases of the heart and blood vessels. It is also used for type 2 diabetes, asthma, lung cancer, endometrial cancer, prostate cancer, and thyroid cancer, as well as preventing weak bones (osteoporosis), and slowing the progression of kidney disease.

Other uses include treating constipation and diarrhea, as well as decreasing protein in the urine of people with kidney disease, improving memory, and treating muscle soreness caused by exercise.

In foods, Isoflavone(CAS NO: 574-12-9) is used as a milk substitute in infant feeding formulas, and as an alternative to cow's milk. Isoflavones are eaten boiled or roasted. Isoflavone flour is used as an ingredient in foods, beverages, and condiments.

The preservation of normal arterial function plays an important role in cardiovascular disease prevention. The ability of arteries to dilate in response to nitric oxide produced by the endothelial cells that line their inner surface (endothelium-mediated vasodilation) is compromised in people at high risk for cardiovascular disease. 

To date, results of randomized controlled trials on the effect of soy isoflavones on arterial function have been mixed. However, most placebo-controlled trials found no significant improvement in endothelium-mediated vasodilation when postmenopausal women were supplemented with up to 80 mg/day of soy isoflavones or up to 60 g/day of soy protein containing isoflavones. Arterial stiffness is another measure of arterial function. Measurements of arterial stiffness assess the distensibility of arteries, and a strong association between arterial stiffness and atherosclerosis has been observed. 

In placebo-controlled clinical trials, supplementation of postmenopausal women with 80 mg/day of a soy isoflavone extract for five weeks significantly decreased arterial stiffness, as did supplementation of men and postmenopausal women with 40 g/day of soy protein providing 118 mg/day of soy isoflavones for three months. 

Although most studies have not found supplementation with soy protein or isoflavones to improve endothelium-mediated vasodilation, preliminary research suggests that soy isoflavone supplementation may decrease arterial stiffness.

However, a recent randomized controlled, cross-over trial in hypertensive individuals found that supplementation with soy protein containing 118 mg/day of isoflavones for six months did not improve measures of arterial function, including arterial stiffness. More research is needed to determine whether supplementation with soy isoflavones improves arterial function.

Want to learn more information about Isoflavone, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.