2-Methyl-4-Isothiazoline-3-one, sometimes erroneously called methylisothiazoline, it is a kind of white to yellow powder with Molecular Formula:C4H5NOS and Molecular Weight:115.15, a powerful biocide and preservative within the group of isothiazolinones, used in personal care products. The CAS Registry Number is 2682-20-4 .
2-Methyl-4-Isothiazoline-3-one is cosmetic preservative. Its main uses are leave-on products, namely hand and body lotions and moisturisers (including facial moisturisers), sun tanning lotions and some rinse-off products like shampoos (mostly zinc pyrithione based anti-dandruff shampoos), surfactants and conditioners.
2-Methyl-4-Isothiazoline-3-one(CAS NO:2682-20-4) is commonly used in products in conjunction with methylchloroisothiazolinone, a mixture sold under the registered trade name Kathon CG. A common indication of sensitivity to Kathon CG is allergic contact dermatitis. Sensitization to this family of preservatives was observed as early as the late 1980s. Due to increased use of isothiazolinone-based preservatives in recent years, an increase in reported incidences of contact allergy to this product have been reported, and in 2013 it was dubbed the 2013 Contact Allergen of the Year.
2-Methyl-4-Isothiazoline-3-one in sterile deionised water has been tested in procaryotic cells for genemutation in several tester strains. The results of the bacterial gene study demonstrated the absence of mutagenic effects in bacteria at the gene level.
Some studies have shown 2-Methyl-4-Isothiazoline-3-one to be allergenic and cytotoxic, and this has led to some concern over its use. In 2002, there was an in vitro study of the neurotoxicity of this compound in the department of Neurobiology at the University of Pittsburgh. In that study, it was shown that a short exposure to concentrations of 2-Methyl-4-Isothiazoline-3-one of 30-100 micromolar were lethal to mature neurons in tissue culture, but not to other brain cells, such as astrocytes .
2-Methyl-4-Isothiazoline-3-one and its closely related analog, chloromethylisothiazolinone or CMIT, affect the ability of young or developing neurons to grow processes in tissue culture. The specific protein affected by 2-Methyl-4-Isothiazoline-3-one is called focal adhesion kinase, or FAK. Normal FAK function is required for the growth of axons and dendrites.
FAK has to be modified by a process called phosphorylation to perform its function, so phosphates are added to FAK’s amino acid chain. It inhibits the tyrosine phosphorylation of FAK by another kinase called Src, preventing the growth of axons and dendrites, at least in culture. These findings were published in the Journal of Pharmacology and Experimental Therapeutics.
The toxic actions of 2-Methyl-4-Isothiazoline-3-one on developing neurons occurs at much lower concentrations than those inducing lethal injury. 2-Methyl-4-Isothiazoline-3-one is even more potent, working at concentrations as low as 0.1 micromolar. One micromolar is approximately 0.115 parts per million.
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2014年1月25日星期六
The uses of N,N-Dimethylethanolamine
N,N-Dimethylethanolamine is a kind of clear to pale yellow liquids with Molecular Formula: C4H11NO and Molecular Weight:89.14. It is miscible with water and soluble in alcohols, diethyl ether. N,N-Dimethylethanolamine forms azeotrope with water. It is related to choline and is a biochemical precursor to the neurotransmitter acetylcholine. It is reported to have nootropic effects, although research on this chemical has found both positive and negative potential results. The CAS Registry Number is 108-01-0.
N,N-Dimethylethanolamine is produced by interaction of excess of dimethylamine with ethylene oxide. It is stable, flammable, and incompatible with oxidizing agents, copper, copper alloys, zinc, acids, galvanised iron. Hygroscopic.
N,N-Dimethylethanolamine(CAS NO: 108-01-0) is applied as corrosion inhibitor, epoxy resins hardener, carbamide resins stabilizer, lubrucant for acetate fibers; It may be used to the synthesis of dyestuffs, textile auxiliaries, ion-exchange and alkyd resins, emulsifiers and bioactive compounds, or as a raw material in preparation of aminoacrylates; It is also used in pharmaceuticals synthesis (dimedrol, pentocain, procaine); It can be used to produce complexing agents ), paint removers; In pharmaceutics (Deanol) as an antidepressive or antidyskinesia agent to treat movement disorders, as a curing agent for polyurethanes and epoxy resins.
After showing you the summary usage of N,N-Dimethylethanolamine, now let me tell the details.
N,N-Dimethylethanolamine is used in the preparation of water-reducible coating formulations. Government regulations covering the amount of organic solvent allowable in the air have spurred a search for emission control procedures. One of the most promising is the replacement of the organic solvent by water. The resins used in coating formulations are not water soluble, but can be made so by reacting them with the amine.
N,N-Dimethylethanolamine can be used to control corrosion in boiler water condensate return lines. The dimethylethanolamine boils with the steam and is carried with it throughout the system. When the steam condenses, the dimethylethanolamine neutralizes any acidic components present in the condensate, thereby controlling the corrosion which would otherwise occur. For more applications, see other applications.
N,N-Dimethylethanolamine is one of the raw materials used to make dimethylaminoethyl methacrylate. Polymers produced from the methacrylate are useful as antistatic agents, soil conditioners, electrically conducting materials, paper auxiliaries, and flocculating agents.
The use of N,N-Dimethylethanolamine has been studied in other applications. Some of these areas are:
1.Preparation of resins which can be used to increase the dry strength or wet strength of paper.
2.Preparation of a good treatment which imparts water repellency and fungus resistance to 3.kiln-dried lumber.
4.Preparation of catalysts for polymerizing olefin oxides and olefin sulfides.
5.Preparation of textile assistants.
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N,N-Dimethylethanolamine is produced by interaction of excess of dimethylamine with ethylene oxide. It is stable, flammable, and incompatible with oxidizing agents, copper, copper alloys, zinc, acids, galvanised iron. Hygroscopic.
N,N-Dimethylethanolamine(CAS NO: 108-01-0) is applied as corrosion inhibitor, epoxy resins hardener, carbamide resins stabilizer, lubrucant for acetate fibers; It may be used to the synthesis of dyestuffs, textile auxiliaries, ion-exchange and alkyd resins, emulsifiers and bioactive compounds, or as a raw material in preparation of aminoacrylates; It is also used in pharmaceuticals synthesis (dimedrol, pentocain, procaine); It can be used to produce complexing agents ), paint removers; In pharmaceutics (Deanol) as an antidepressive or antidyskinesia agent to treat movement disorders, as a curing agent for polyurethanes and epoxy resins.
After showing you the summary usage of N,N-Dimethylethanolamine, now let me tell the details.
N,N-Dimethylethanolamine is used in the preparation of water-reducible coating formulations. Government regulations covering the amount of organic solvent allowable in the air have spurred a search for emission control procedures. One of the most promising is the replacement of the organic solvent by water. The resins used in coating formulations are not water soluble, but can be made so by reacting them with the amine.
N,N-Dimethylethanolamine can be used to control corrosion in boiler water condensate return lines. The dimethylethanolamine boils with the steam and is carried with it throughout the system. When the steam condenses, the dimethylethanolamine neutralizes any acidic components present in the condensate, thereby controlling the corrosion which would otherwise occur. For more applications, see other applications.
N,N-Dimethylethanolamine is one of the raw materials used to make dimethylaminoethyl methacrylate. Polymers produced from the methacrylate are useful as antistatic agents, soil conditioners, electrically conducting materials, paper auxiliaries, and flocculating agents.
The use of N,N-Dimethylethanolamine has been studied in other applications. Some of these areas are:
1.Preparation of resins which can be used to increase the dry strength or wet strength of paper.
2.Preparation of a good treatment which imparts water repellency and fungus resistance to 3.kiln-dried lumber.
4.Preparation of catalysts for polymerizing olefin oxides and olefin sulfides.
5.Preparation of textile assistants.
Want to learn more information about N,N-Dimethylethanolamine, you can access to our guidechem. Guidechem is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
2014年1月24日星期五
The way to preparation of 2,4-Difluorobenzoic acid
2,4-Difluorobenzoic acid is a kind of white to light yellow crystal powders with Molecular Formula: C7H4F2O2 and Molecular Weight: 158.1. It is soluble in water, stable at room temperature in closed containers under normal storage and handling conditions. We should store it in a tightly closed container. Store it in a cool, dry, well-ventilated area away from incompatible substances. The CAS Registry Number is 1583-58-0.
This invention relates to a method for the preparation of 2,4-Difluorobenzoic acid. It has been prepared by the oxidation of the corresponding toluene derivative. More particularly, this invention relates to a process for the preparation of 2,4-Difluorobenzoic acid by the decarboxylation of 4,5,-difluorophthalic anhydride or 4,5-difluorophthalic acid in which the decarboxylation reaction is conducted in N-methylpyrrolidone or dimethyl acetamide. Copper catalysts may be used in this reaction.
2,4-Difluorobenzoic acid(CAS NO: 1583-58-0) is a useful chemical intermediate. For example, it has been used as an intermediate in the preparation of potential anti-cancer agents. In addition, it has been used in the synthesis of antidepressant drugs. Attempts were made to prepare 2,4-Difluorobenzoic acid by decarboxylation of 4,5-difluorophthalic anhydride. It may be readily prepared by the reaction of 4,5-dichlorophthalic anhydride with potassium fluoride as disclosed in U.S. Pat. No. 4,374,266 . The acid may be readily prepared by reacting the anhydride with water.
The decarboxylation of 4,5-difluorophthalic anhydride proved to be difficult, since previously known methods of decarboxylation led to a low yield of the desired product along with numerous by-products. The following chart illustrates the decarboxylation methods which were tested. The percentage product shown in the results were those obtained by gas chromatographic analysis, DFBA stands for 2,4-Difluorobenzoic acid s.m. stands for starting material.
The difluorobenzoic acid may be isolated from the reaction mixture by acidifying the mixture and extracting with a suitable solvent such as ethyl acetate or diethyl ether. Evaporation of the solvent yields crude difluorobenzoic acid which may be recrystallized/decolorized by using water and activated carbon.
We have found that 4,5-difluorophthalic anhydride and 4,5-difluorophthalic acid may be decarboxylated in high yield to 2,4-Difluorobenzoic acid in N-methyl-2-pyrrolidone or dimethyl acetamide using copper, copper oxide, copper salts, or halides and salts of Zn, Cd, Ag and Ni as a catalyst.
Surprisingly, we have found that 4,5-difluorophthalic anhydride and 4,5-difluorophthalic acid may be selectively decarboxylated in N-methyl-pyrrolidone, dimethyl acetamide or quinoline to yield 2,4-Difluorobenzoic acid.
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This invention relates to a method for the preparation of 2,4-Difluorobenzoic acid. It has been prepared by the oxidation of the corresponding toluene derivative. More particularly, this invention relates to a process for the preparation of 2,4-Difluorobenzoic acid by the decarboxylation of 4,5,-difluorophthalic anhydride or 4,5-difluorophthalic acid in which the decarboxylation reaction is conducted in N-methylpyrrolidone or dimethyl acetamide. Copper catalysts may be used in this reaction.
2,4-Difluorobenzoic acid(CAS NO: 1583-58-0) is a useful chemical intermediate. For example, it has been used as an intermediate in the preparation of potential anti-cancer agents. In addition, it has been used in the synthesis of antidepressant drugs. Attempts were made to prepare 2,4-Difluorobenzoic acid by decarboxylation of 4,5-difluorophthalic anhydride. It may be readily prepared by the reaction of 4,5-dichlorophthalic anhydride with potassium fluoride as disclosed in U.S. Pat. No. 4,374,266 . The acid may be readily prepared by reacting the anhydride with water.
The decarboxylation of 4,5-difluorophthalic anhydride proved to be difficult, since previously known methods of decarboxylation led to a low yield of the desired product along with numerous by-products. The following chart illustrates the decarboxylation methods which were tested. The percentage product shown in the results were those obtained by gas chromatographic analysis, DFBA stands for 2,4-Difluorobenzoic acid s.m. stands for starting material.
The difluorobenzoic acid may be isolated from the reaction mixture by acidifying the mixture and extracting with a suitable solvent such as ethyl acetate or diethyl ether. Evaporation of the solvent yields crude difluorobenzoic acid which may be recrystallized/decolorized by using water and activated carbon.
We have found that 4,5-difluorophthalic anhydride and 4,5-difluorophthalic acid may be decarboxylated in high yield to 2,4-Difluorobenzoic acid in N-methyl-2-pyrrolidone or dimethyl acetamide using copper, copper oxide, copper salts, or halides and salts of Zn, Cd, Ag and Ni as a catalyst.
Surprisingly, we have found that 4,5-difluorophthalic anhydride and 4,5-difluorophthalic acid may be selectively decarboxylated in N-methyl-pyrrolidone, dimethyl acetamide or quinoline to yield 2,4-Difluorobenzoic acid.
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Mebendazole is an important medicine
Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, whipworm, threadworm, and hookworm. It is poorly absorbed and has no systemic effects. It is a kind of white to yellowish powders with Molecular Formula: C16H13N3O3 and Molecular Weight: 295.3. The CAS Registry Number is 31431-39-7.
It is used to treat intestinal worm infections such as pinworm, roundworm, and hookworm. It may also be used for worm infections elsewhere in the body (e.g., trichinosis). In these cases, it is usually taken more often and for a longer time.
Mebendazole(CAS NO:31431-39-7) is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells, thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths.
It comes as a chewable tablet. It usually is taken twice a day, in the morning and evening, for 3 days or as a single (one-time) dose. You may chew the tablets, swallow them whole, or crush and mix them with food. Treatment may have to be repeated in 2-3 weeks. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take mebendazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Oral dosage for treatment of pinworms is 100 mg taken once. (500 mg can also be taken instead) This regimen is repeated two weeks later if the infestation has not cleared up. Oral dosage for treatment of whipworm, common roundworm and hookworm is one 100-mg tablet in the morning for three consecutive days in children below 5yrs of age and below 18 kg weight. In adults it is 100 mg twice a day.
It is very important to continue taking this medication exactly as prescribed by your doctor. Do not skip any doses. Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear. Stopping the medication too early may result in a return of the infection.
In deciding to use Mebendazole, the risks of taking Mebendazole must be weighed against the good it will do. This is a decision you and your doctor will make. For mebendazole, the following should be considered: Allergies,Pediatric,Geriatric,Pregnancy,Breast Feeding.
Mebendazole is relatively free of toxic side effects or adverse reactions, although patients may complain of transient abdominal pain, heart pain, diarrhea, slight headache, fever, dizziness, exanthema, urticaria, and angioedema.
If you need take Mebendazole, you should pay more attention to it. Learning more health information, properties or suppliers about Mebendazole, you can access Guidechem.
It is used to treat intestinal worm infections such as pinworm, roundworm, and hookworm. It may also be used for worm infections elsewhere in the body (e.g., trichinosis). In these cases, it is usually taken more often and for a longer time.
Mebendazole(CAS NO:31431-39-7) is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells, thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths.
It comes as a chewable tablet. It usually is taken twice a day, in the morning and evening, for 3 days or as a single (one-time) dose. You may chew the tablets, swallow them whole, or crush and mix them with food. Treatment may have to be repeated in 2-3 weeks. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take mebendazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Oral dosage for treatment of pinworms is 100 mg taken once. (500 mg can also be taken instead) This regimen is repeated two weeks later if the infestation has not cleared up. Oral dosage for treatment of whipworm, common roundworm and hookworm is one 100-mg tablet in the morning for three consecutive days in children below 5yrs of age and below 18 kg weight. In adults it is 100 mg twice a day.
It is very important to continue taking this medication exactly as prescribed by your doctor. Do not skip any doses. Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear. Stopping the medication too early may result in a return of the infection.
In deciding to use Mebendazole, the risks of taking Mebendazole must be weighed against the good it will do. This is a decision you and your doctor will make. For mebendazole, the following should be considered: Allergies,Pediatric,Geriatric,Pregnancy,Breast Feeding.
Mebendazole is relatively free of toxic side effects or adverse reactions, although patients may complain of transient abdominal pain, heart pain, diarrhea, slight headache, fever, dizziness, exanthema, urticaria, and angioedema.
If you need take Mebendazole, you should pay more attention to it. Learning more health information, properties or suppliers about Mebendazole, you can access Guidechem.
2014年1月23日星期四
p-Toluenesulfonamide for the environment
IUPAC Name: 4-Methylbenzenesulfonamide
Molecular Formula: C7H9NO2S
Molecular Weight: 171.21 g/mol
EINECS: 200-741-1
Melting Point: 134-137 C(lit.)
Water Solubility: 0.32 g/100 mL (25 C)
Index of Refraction: 1.564
Molar Refractivity: 43.81 cm3
Molar Volume: 134.6 cm3
Surface Tension: 46.3 dyne/cm
Density: 1.271 g/cm3
Flash Point: 148.6 C
Enthalpy of Vaporization: 56.4 kJ/mol
Boiling Point: 322.2 C at 760 mmHg
CAS NO: 70-55-3
A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3:2 cocrystal in the presence of excess sulfonamide. Both cocrystals are stable in the solid state.
The ternary phase diagram for the two coformers was constructed in two different solvents: acetonitrile and dichloromethane. Examination of these diagrams clarified solution crystallization of both the newly discovered 1:1 cocrystal and the previously reported 3:2 cocrystal, and identified regions of stability for each cocrystal in each solvent. The choice of solvent was found to have a significant effect on the position of the solid state regions within a cocrystal system.
p-Toluenesulfonamide's production and use in organic synthesis, as a fungicide and mildewicide in paints and coatings,and in plasticizers and resins may result in its release to the environment through various waste streams. It has been detected in drinking water, surface water, ground water and in the effluents from the non ferrous metals and the printing and publishing industries. If released to soil, p-toluenesulfonamide(CAS NO:70-55-3) should have high mobility.
Volatilization of p-toluenesulfonamide should not be important from moist or dry soil surfaces. p-Toluenesulfonamide will not be susceptible to direct photolysis on soil surfaces based on its lack of absorption of light at wavelengths >290 nm. Anaerobic biodegradation of p-toluenesulfonamide in soil and water is not expected to be an important fate process according to a biodegradation study conducted in anaerobic aquifer slurries. The importance of aerobic biodegradation is unknown.
However, the lack of biodegradation in the MITI test of the ortho isomer suggests that aerobic biodegradation of p-toluenesulfonamide may be slow. If released to water, p-toluenesulfonamide should not adsorb to suspended solids and sediment. p-Toluenesulfonamide will be essentially non-volatile from water surfaces. An estimated BCF value of 2.5 suggests that it will not bioconcentrate in aquatic organisms. If released to the atmosphere, p-toluenesulfonamide will exist as both a vapor and particulate in the ambient atmosphere.
Vapor-phase p-toluenesulfonamide is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of about 13 days. Particulate-phase p-toluenesulfonamide may be physically removed from the air by wet and dry deposition.
Want to learn more information about p-toluenesulfonamide, you can access the guidechem.com.
Molecular Formula: C7H9NO2S
Molecular Weight: 171.21 g/mol
EINECS: 200-741-1
Melting Point: 134-137 C(lit.)
Water Solubility: 0.32 g/100 mL (25 C)
Index of Refraction: 1.564
Molar Refractivity: 43.81 cm3
Molar Volume: 134.6 cm3
Surface Tension: 46.3 dyne/cm
Density: 1.271 g/cm3
Flash Point: 148.6 C
Enthalpy of Vaporization: 56.4 kJ/mol
Boiling Point: 322.2 C at 760 mmHg
CAS NO: 70-55-3
A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3:2 cocrystal in the presence of excess sulfonamide. Both cocrystals are stable in the solid state.
The ternary phase diagram for the two coformers was constructed in two different solvents: acetonitrile and dichloromethane. Examination of these diagrams clarified solution crystallization of both the newly discovered 1:1 cocrystal and the previously reported 3:2 cocrystal, and identified regions of stability for each cocrystal in each solvent. The choice of solvent was found to have a significant effect on the position of the solid state regions within a cocrystal system.
p-Toluenesulfonamide's production and use in organic synthesis, as a fungicide and mildewicide in paints and coatings,and in plasticizers and resins may result in its release to the environment through various waste streams. It has been detected in drinking water, surface water, ground water and in the effluents from the non ferrous metals and the printing and publishing industries. If released to soil, p-toluenesulfonamide(CAS NO:70-55-3) should have high mobility.
Volatilization of p-toluenesulfonamide should not be important from moist or dry soil surfaces. p-Toluenesulfonamide will not be susceptible to direct photolysis on soil surfaces based on its lack of absorption of light at wavelengths >290 nm. Anaerobic biodegradation of p-toluenesulfonamide in soil and water is not expected to be an important fate process according to a biodegradation study conducted in anaerobic aquifer slurries. The importance of aerobic biodegradation is unknown.
However, the lack of biodegradation in the MITI test of the ortho isomer suggests that aerobic biodegradation of p-toluenesulfonamide may be slow. If released to water, p-toluenesulfonamide should not adsorb to suspended solids and sediment. p-Toluenesulfonamide will be essentially non-volatile from water surfaces. An estimated BCF value of 2.5 suggests that it will not bioconcentrate in aquatic organisms. If released to the atmosphere, p-toluenesulfonamide will exist as both a vapor and particulate in the ambient atmosphere.
Vapor-phase p-toluenesulfonamide is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of about 13 days. Particulate-phase p-toluenesulfonamide may be physically removed from the air by wet and dry deposition.
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Acetoacetanilide for the environment and hunman health
Acetoacetanilide is a chemical intermediate used in the production of pigments. It is a kind of white to off-white powder, with Molecular Formula:C10H11NO2 and Molecular Weight:177.2. It is stable, combustible,incompatible with strong oxidizing agents. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. The CAS Registry Number is 102-01-2.
Acetoacetanilide is used as intermediate for the manufacture of organic pigments and dyestuffs. It is then isolated and transported under closed conditions to pigment manufacturing facilities. There is no known direct or consumer use. Non-aqueouswastes from manufacture are incinerated, and aqueous wastes are sent to a wastewater treatment facility for treatment.
For the environment, Acetoacetanilide(CAS NO: 102-01-2) is of low concern to aquatic organisms and is considered inherently biodegradable. The predicted environmental concentration is lower than the predicted no effect concentration. It is therefore currently considered of low potential risk and low priority for further work.
It is a solid with a low vapor pressure therefore; substantial airborne concentrations are not likely. Solubility studies indicate that it in the environment will partition into water, where biodegradation then occurs. Data from environmental toxicity studies indicate that Acetacetanilide is of low concern for aquatic or plant species.
Emissions to the terrestrial environment are not considered, as there is no direct release to soil and no emission to air. Based on the results from the use emission scenarios it can be concluded that Acetoacetanilide will not cause any harmful effects on the environment during the whole life cycle. With regards to the proposed emission scenarios, it is of no immediate concern for the environment.
For the hunman health, the intended uses of Acetoacetanilide are industrial only, and there are no downstream uses that would result in exposure of consumers. It is used as intermediate and the amount of residual starting material in the end products is negligible.
Considering the work pattern in the uses of Acetoacetanilide and the non-relevance of indirect exposure it can be excluded that workers are exposed to Acetoacetanilide from more than one emission source. According to the Exposure Scenarios, Acetoacetanilide does not pose an unacceptable risk to human health. Overall the substance is of no immediate concern for man when used within the boundaries of the operational controls and risk management measures described for its uses.
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Acetoacetanilide is used as intermediate for the manufacture of organic pigments and dyestuffs. It is then isolated and transported under closed conditions to pigment manufacturing facilities. There is no known direct or consumer use. Non-aqueouswastes from manufacture are incinerated, and aqueous wastes are sent to a wastewater treatment facility for treatment.
For the environment, Acetoacetanilide(CAS NO: 102-01-2) is of low concern to aquatic organisms and is considered inherently biodegradable. The predicted environmental concentration is lower than the predicted no effect concentration. It is therefore currently considered of low potential risk and low priority for further work.
It is a solid with a low vapor pressure therefore; substantial airborne concentrations are not likely. Solubility studies indicate that it in the environment will partition into water, where biodegradation then occurs. Data from environmental toxicity studies indicate that Acetacetanilide is of low concern for aquatic or plant species.
Emissions to the terrestrial environment are not considered, as there is no direct release to soil and no emission to air. Based on the results from the use emission scenarios it can be concluded that Acetoacetanilide will not cause any harmful effects on the environment during the whole life cycle. With regards to the proposed emission scenarios, it is of no immediate concern for the environment.
For the hunman health, the intended uses of Acetoacetanilide are industrial only, and there are no downstream uses that would result in exposure of consumers. It is used as intermediate and the amount of residual starting material in the end products is negligible.
Considering the work pattern in the uses of Acetoacetanilide and the non-relevance of indirect exposure it can be excluded that workers are exposed to Acetoacetanilide from more than one emission source. According to the Exposure Scenarios, Acetoacetanilide does not pose an unacceptable risk to human health. Overall the substance is of no immediate concern for man when used within the boundaries of the operational controls and risk management measures described for its uses.
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2014年1月22日星期三
Research on Formononetin
Formononetin is an O-methylated isoflavon, an active constituent of the Chinese herb Astragali Radix, has been reported to have beneficial effects for Alzheimer's disease (AD). It is a kind of off-white powders, he Molecular Formula is C16H12O4, Molecular Weight is 268.27. We should store it in a cool, dry place and in a tightly closed container. The CAS Registry Number of Formononetin is 485-72-3.
Formononetin is found in a number of plants and herbs like the red clover. Along with other phytoestrogens, it predominantly occurs in leguminous plants and Fabaceae, particularly in beans, such as green beans, lima beans, soy and many others, as the free aglycone or in form of its glucoside ononin.It can also be found in Maackia amurensis cell cultures.
The present study shows that formononetin(CAS NO:485-72-3) increases soluble-AβPPαsecretion and thus protects human-AβPP Swedish mutation cell from hypoxia-induced apoptosis. Using hypoxic N2a-AβPP cell as an in vitro model of AD-like pathology, we confirmed that regular treatment with formononetin could have neuroprotective effects, followed respectively by reduced caspase 3 activity and increased cell viability.
Strikingly, our data revealed that the caspase 3-blocking effect of formononetin was largely mediated by stimulation of α-secretase cleavage of AβPP, and increasing the secretion of its soluble form, sAβPPα. Moreover, the protective effect of formononetin was totally inhibited by TAPI-2, an α-secretase complex inhibitor, suggesting the role of the sAβPPαpathway in the neuroprotective response to formononetin.
We also found that the stimulative effect of formononetin onα-secretase activity was mainly conducted by upregulating ADAM10 expression at the transcriptional level. Altogether, our study provides novel insights into how formononetin mediates stimulation of the ADAM10-sAβPPα pathway and exerts a neuronal protective effect.
Formononetin and equol, a secondary metabolite of formononetin, have been reported to be responsible for reproductive dysfunction and infertility in ruminants. The hormonal effects of formononetin may have a possible influence on breast cancer risk in mice, since it has been reported that formononetin supported mammary gland, pro-liferation, enhanced mammary estrogen receptor expres-sion, and increased circulating prolactin level in an estrogen-deficient murine model. However, ER binding of formonetin has much lower affinity than daidzein and equol, which are metabolites of formononetin.
Equol was proposed to be the major active phytoestrogen found in sheep and cattle that consumed alfalfa or clover. Aglycone and conjugated forms of formononetin, daidzein, and equol have also been detected in bovine blood plasma and urine from cows fed a diet containing daidzein and formononetin.
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Formononetin is found in a number of plants and herbs like the red clover. Along with other phytoestrogens, it predominantly occurs in leguminous plants and Fabaceae, particularly in beans, such as green beans, lima beans, soy and many others, as the free aglycone or in form of its glucoside ononin.It can also be found in Maackia amurensis cell cultures.
The present study shows that formononetin(CAS NO:485-72-3) increases soluble-AβPPαsecretion and thus protects human-AβPP Swedish mutation cell from hypoxia-induced apoptosis. Using hypoxic N2a-AβPP cell as an in vitro model of AD-like pathology, we confirmed that regular treatment with formononetin could have neuroprotective effects, followed respectively by reduced caspase 3 activity and increased cell viability.
Strikingly, our data revealed that the caspase 3-blocking effect of formononetin was largely mediated by stimulation of α-secretase cleavage of AβPP, and increasing the secretion of its soluble form, sAβPPα. Moreover, the protective effect of formononetin was totally inhibited by TAPI-2, an α-secretase complex inhibitor, suggesting the role of the sAβPPαpathway in the neuroprotective response to formononetin.
We also found that the stimulative effect of formononetin onα-secretase activity was mainly conducted by upregulating ADAM10 expression at the transcriptional level. Altogether, our study provides novel insights into how formononetin mediates stimulation of the ADAM10-sAβPPα pathway and exerts a neuronal protective effect.
Formononetin and equol, a secondary metabolite of formononetin, have been reported to be responsible for reproductive dysfunction and infertility in ruminants. The hormonal effects of formononetin may have a possible influence on breast cancer risk in mice, since it has been reported that formononetin supported mammary gland, pro-liferation, enhanced mammary estrogen receptor expres-sion, and increased circulating prolactin level in an estrogen-deficient murine model. However, ER binding of formonetin has much lower affinity than daidzein and equol, which are metabolites of formononetin.
Equol was proposed to be the major active phytoestrogen found in sheep and cattle that consumed alfalfa or clover. Aglycone and conjugated forms of formononetin, daidzein, and equol have also been detected in bovine blood plasma and urine from cows fed a diet containing daidzein and formononetin.
Want to learn more information about Formononetin, you can access to our guidechem.
Synthesize 4-Methoxyphenol from p-Anisaldehyde
4-Methoxyphenol is a kind of pink crystals or white waxy solid, also known as Mequinol which is a drug used in combination with the drug tretinoin in the treatment of liver spots. It used alone and in higher doses is used as a topical drug for medical depigmentation. The Molecular Formula is C7H8O2, Molecular Weight is 124.14, EINECS is 205-769-8. 4-Methoxyphenol is stable, combustible, incompatible with halogens, oxidizing agents. The CAS Registry Number of 4-Methoxyphenol is 150-76-5. We should store it in a cool, dry place and store it in a tightly closed container.
It is the monomethyl ether of hydroquinone, and an isomer of guaiacol.It is often used to inhibit polymerization in monomers that polymerize with radical mechanisms, such as acrylates, methacrylates or styrene. In this article, I will show you how to synthesize 4-Methoxyphenol(CAS NO:150-76-5) from p-Anisaldehyde.
Firstly, in a 500 mL flask were placed 5.0 g (36.7 mmol) of p-anisaldehyde and 184 mL of methylene chloride (0.2M). This mixture was vigorously stirred with a magnetic stir bar. To the homogeneous solution was added 9.37 mL of 30% aqueous hydrogen peroxide (92.0 mmol., 2.5 equivalents) and 5.54 mL of formic acid (147 mmol., 4.0 equivalents). The flask was then fitted with a reflux condenser and heated to reflux for 20.5 hours with stirring.
After cooling, 119 mL of 1.5N sodium hydroxide (179 mmol., 4.86 equivalents) was added to the flask. The mixture was stirred for 15 minutes. The organic layer was separated and concentrated to a residue using a rotary evaporator. The residue was combined with the aqueous solution and 79.3 mL of methanol was added. The solution was stirred for 30 minutes. The methanol was removed using a rotary evaporator.
The neutral materials were removed from the aqueous residue by extracting with two 100 mL portions of methylene chloride. The solution was adjusted to a pH of 1 to 2 with concentrated hydrochloric acid. The 4-methoxyphenol was extracted with three 100 mL portions of methylene chloride.
The organic solution containing the neutrals as well as the one containing the product were separately dried over anhydrous magnesium sulfate and filtered into tared round-bottom flasks. The methylene chloride was removed using a rotary evaporator. A total of 0.052 g of neutrals was recovered. A total of 4.13 g of the crude 4-methoxyphenol was obtained.
The 4-methoxyphenol was purified utilizing bulb-to-bulb distillation. A mass of 3.88 g of 4-methoxyphenol as a white crystalline solid was obtained. The purity was determined by GC as well as HPLC.
Now have got this simple way to synthesize 4-Methoxyphenol? Want to learn more information about 4-Methoxyphenol, you can access our guidechem. Guidechem is just a place for you to look for some chemicals.
It is the monomethyl ether of hydroquinone, and an isomer of guaiacol.It is often used to inhibit polymerization in monomers that polymerize with radical mechanisms, such as acrylates, methacrylates or styrene. In this article, I will show you how to synthesize 4-Methoxyphenol(CAS NO:150-76-5) from p-Anisaldehyde.
Firstly, in a 500 mL flask were placed 5.0 g (36.7 mmol) of p-anisaldehyde and 184 mL of methylene chloride (0.2M). This mixture was vigorously stirred with a magnetic stir bar. To the homogeneous solution was added 9.37 mL of 30% aqueous hydrogen peroxide (92.0 mmol., 2.5 equivalents) and 5.54 mL of formic acid (147 mmol., 4.0 equivalents). The flask was then fitted with a reflux condenser and heated to reflux for 20.5 hours with stirring.
After cooling, 119 mL of 1.5N sodium hydroxide (179 mmol., 4.86 equivalents) was added to the flask. The mixture was stirred for 15 minutes. The organic layer was separated and concentrated to a residue using a rotary evaporator. The residue was combined with the aqueous solution and 79.3 mL of methanol was added. The solution was stirred for 30 minutes. The methanol was removed using a rotary evaporator.
The neutral materials were removed from the aqueous residue by extracting with two 100 mL portions of methylene chloride. The solution was adjusted to a pH of 1 to 2 with concentrated hydrochloric acid. The 4-methoxyphenol was extracted with three 100 mL portions of methylene chloride.
The organic solution containing the neutrals as well as the one containing the product were separately dried over anhydrous magnesium sulfate and filtered into tared round-bottom flasks. The methylene chloride was removed using a rotary evaporator. A total of 0.052 g of neutrals was recovered. A total of 4.13 g of the crude 4-methoxyphenol was obtained.
The 4-methoxyphenol was purified utilizing bulb-to-bulb distillation. A mass of 3.88 g of 4-methoxyphenol as a white crystalline solid was obtained. The purity was determined by GC as well as HPLC.
Now have got this simple way to synthesize 4-Methoxyphenol? Want to learn more information about 4-Methoxyphenol, you can access our guidechem. Guidechem is just a place for you to look for some chemicals.
2014年1月21日星期二
The basic usages of D(+)-Sucrose
D(+)-Sucrose is the organic compound commonly known as table sugar and sometimes called saccharose. It is a white crystals or powder with a sweet taste. The Molecular Formula of D(+)-Sucrose is C12H22O11, and Molecular Weight is 342.3. However the CAS Registry Number is 57-50-1.
D(+)-Sucrose is a molecule with nine stereocenters and many sites that are reactive or can be reactive. The molecule exists as a single isomer. The purity of sucrose is measured by polarimetry, through the rotation of plane-polarized light by a solution of sugar. The specific rotation at 20 C using yellow "sodium-D" light (589 nm) is +66.47 C. Commercial samples of sugar are assayed using this parameter. Sucrose does not deteriorate at ambient conditions.
In Sucrose, the components glucose and fructose are linked via an ether bond between C1 on the glucosyl subunit and C2 on the fructosyl unit. The bond is called a glycosidic linkage. Glucose exists predominantly as two isomeric "pyranoses" (α and β), but only one of these forms links to the fructose. Fructose itself exists as a mixture of "furanoses", each of which having α and β isomers, but only one particular isomer links to the glucosyl unit.
D(+)-Sucrose(CAS NO: 57-50-1) is a nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons. It is obtained commercially from sugarcane, sugar beet , and other plants and used extensively as a food and a sweetener.
D(+)-Sucrose is derived by crushing and extraction of sugarcane with water or extraction of the sugar beet with water, evaporating, and purifying with lime, carbon, and various liquids. It is also obtainable from sorghum. It occurs in low percentages in honey and maple syrup. It is used as a sweetener in foods and soft drinks, in the manufacture of syrups, in invert sugar, confectionery, preserves and jams, demulcent, pharmaceutical products, and caramel.
D(+)-Sucrose is also a chemical intermediate for detergents, emulsifying agents, and other sucrose derivatives. D(+)-Sucrose is widespread in seeds, leaves, fruits, flowers and roots of plants, where it functions as an energy store for metabolism and as a carbon source for biosynthesis.
The annual world production of D(+)-Sucrose is in excess of 90 million tons mainly from the juice of sugar cane (20%) and sugar beet (17%). In addition to its use as a sweetner, D(+)-Sucrose is used in food products as a preservative, antioxidant, moisture control agent, stabilizer and thickening agent.
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D(+)-Sucrose is a molecule with nine stereocenters and many sites that are reactive or can be reactive. The molecule exists as a single isomer. The purity of sucrose is measured by polarimetry, through the rotation of plane-polarized light by a solution of sugar. The specific rotation at 20 C using yellow "sodium-D" light (589 nm) is +66.47 C. Commercial samples of sugar are assayed using this parameter. Sucrose does not deteriorate at ambient conditions.
In Sucrose, the components glucose and fructose are linked via an ether bond between C1 on the glucosyl subunit and C2 on the fructosyl unit. The bond is called a glycosidic linkage. Glucose exists predominantly as two isomeric "pyranoses" (α and β), but only one of these forms links to the fructose. Fructose itself exists as a mixture of "furanoses", each of which having α and β isomers, but only one particular isomer links to the glucosyl unit.
D(+)-Sucrose(CAS NO: 57-50-1) is a nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons. It is obtained commercially from sugarcane, sugar beet , and other plants and used extensively as a food and a sweetener.
D(+)-Sucrose is derived by crushing and extraction of sugarcane with water or extraction of the sugar beet with water, evaporating, and purifying with lime, carbon, and various liquids. It is also obtainable from sorghum. It occurs in low percentages in honey and maple syrup. It is used as a sweetener in foods and soft drinks, in the manufacture of syrups, in invert sugar, confectionery, preserves and jams, demulcent, pharmaceutical products, and caramel.
D(+)-Sucrose is also a chemical intermediate for detergents, emulsifying agents, and other sucrose derivatives. D(+)-Sucrose is widespread in seeds, leaves, fruits, flowers and roots of plants, where it functions as an energy store for metabolism and as a carbon source for biosynthesis.
The annual world production of D(+)-Sucrose is in excess of 90 million tons mainly from the juice of sugar cane (20%) and sugar beet (17%). In addition to its use as a sweetner, D(+)-Sucrose is used in food products as a preservative, antioxidant, moisture control agent, stabilizer and thickening agent.
Want to learn more information about D(+)-Sucrose, you can access to our Guidechem. Guidechem is just a place for you to look for some chemicals. It provides the most convenient conditions for the international buyers and let these leads benefit all the business people.
2014年1月20日星期一
The medicial use of Naphthalene
Naphthalene is a kind of white to almost white crystals or crystalline flakes with Molecular Formula C10H8. It is the simplest polycyclic aromatic hydrocarbon, with a characteristic odor that is detectable at concentrations as low as 0.08 ppm by mass.
As an aromatic hydrocarbon, naphthalene's structure consists of a fused pair of benzene rings. It is best known as the main ingredient of traditional mothballs. Its Molecular Weight is 128.17, and CAS Registry Number is 91-20-3.
The primary use for naphthalene is in the production of phthalic anhydride. However, o-xylene is replacing naphthalene as the preferred raw material for phthalic anhydride production. Other uses of naphthalene include carbamate insecticides, surface active agents and resins, as a dye intermediate, as a synthetic tanning agent, as a moth repellent, and in miscellaneous organic chemicals.
The most important use of Naphthalene(CAS NO:91-20-3) is used as medicine.
Naphthalene can enter your body when you breathe contaminated air or eat and drink contaminated food and water. Once inside your body, it can damage the body’s redblood cells. It also changes into other chemicals and leaves your body through urine in just a matter of days.
It is used mainly as a precursor to other chemicals. The single largest use of naphthalene is the industrial production of phthalic anhydride, although more phthalic anhydride is made from o-xylene. Other naphthalene-derived chemicals include alkyl naphthalene sulfonate surfactants, and the insecticide 1-naphthyl-N-methylcarbamate .
It substituted with combinations of strongly electron-donating functional groups, such as alcohols and amines, and strongly electron-withdrawing groups, especially sulfonic acids, are intermediates in the preparation of many synthetic dyes. The hydrogenated naphthalenes tetrahydronaphthalene (tetralin) and decahydronaphthalene (decalin) are used as low-volatility solvents. Naphthalene is also used in the synthesis of 2-naphthol, a precursor for various dyestuffs, pigments, rubber processing chemicals and other miscellaneous chemicals and pharmaceuticals.
Naphthalene sulfonic acids are used in the manufacture of naphthalene sulfonate polymer plasticizers (dispersants), which are used to produce concrete and plasterboard (wallboard or drywall). They are also used as dispersants in synthetic and natural rubbers, and as tanning agents (syntans) in leather industries, agricultural formulations (dispersants for pesticides), dyes and as a dispersant in lead–acid battery plates.
Naphthalene sulfonate polymers are produced by reacting naphthalene with sulfuric acid and then polymerizing with formaldehyde, followed by neutralization with sodium hydroxide or calcium hydroxide. These products are commercially sold in solution (water) or dry powder form.
If you need take Naphthalene, you should pay more attention to it. Learning more health information, properties or suppliers about Naphthalene, you can access Guidechem. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
As an aromatic hydrocarbon, naphthalene's structure consists of a fused pair of benzene rings. It is best known as the main ingredient of traditional mothballs. Its Molecular Weight is 128.17, and CAS Registry Number is 91-20-3.
The primary use for naphthalene is in the production of phthalic anhydride. However, o-xylene is replacing naphthalene as the preferred raw material for phthalic anhydride production. Other uses of naphthalene include carbamate insecticides, surface active agents and resins, as a dye intermediate, as a synthetic tanning agent, as a moth repellent, and in miscellaneous organic chemicals.
The most important use of Naphthalene(CAS NO:91-20-3) is used as medicine.
Naphthalene can enter your body when you breathe contaminated air or eat and drink contaminated food and water. Once inside your body, it can damage the body’s redblood cells. It also changes into other chemicals and leaves your body through urine in just a matter of days.
It is used mainly as a precursor to other chemicals. The single largest use of naphthalene is the industrial production of phthalic anhydride, although more phthalic anhydride is made from o-xylene. Other naphthalene-derived chemicals include alkyl naphthalene sulfonate surfactants, and the insecticide 1-naphthyl-N-methylcarbamate .
It substituted with combinations of strongly electron-donating functional groups, such as alcohols and amines, and strongly electron-withdrawing groups, especially sulfonic acids, are intermediates in the preparation of many synthetic dyes. The hydrogenated naphthalenes tetrahydronaphthalene (tetralin) and decahydronaphthalene (decalin) are used as low-volatility solvents. Naphthalene is also used in the synthesis of 2-naphthol, a precursor for various dyestuffs, pigments, rubber processing chemicals and other miscellaneous chemicals and pharmaceuticals.
Naphthalene sulfonic acids are used in the manufacture of naphthalene sulfonate polymer plasticizers (dispersants), which are used to produce concrete and plasterboard (wallboard or drywall). They are also used as dispersants in synthetic and natural rubbers, and as tanning agents (syntans) in leather industries, agricultural formulations (dispersants for pesticides), dyes and as a dispersant in lead–acid battery plates.
Naphthalene sulfonate polymers are produced by reacting naphthalene with sulfuric acid and then polymerizing with formaldehyde, followed by neutralization with sodium hydroxide or calcium hydroxide. These products are commercially sold in solution (water) or dry powder form.
If you need take Naphthalene, you should pay more attention to it. Learning more health information, properties or suppliers about Naphthalene, you can access Guidechem. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
2014年1月19日星期日
Maleic acid is not allowed to add in food
Maleic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. It has the Molecular Formula:C4H4O4 and Molecular Weight:116.07. It is stable,combustible and incompatible with strong oxidizing agents, bases. The CAS Registry Number is 110-16-7. It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications.
Maleic acid is not very important economically, since the anhydride is easier to use. It is employed in the manufacture of phthalic-type alkyd and polyester resins, surface coatings, copolymers, plasticizers, lubricant additives and agricultural chemicals; in adhesives and sealants; as a preservative for oils and fats; organic synthesis; dyeing and finishing wool, cotton and silk; and preparing the maleate salts of antihistamines and similar drugs.
Maleic acid(CAS NO:110-16-7) is not a kind of food additives, but some unscrupulous manufacturers ued Maleic acid in some food. Here is a case about Maleic acid used as food additive in Taiwan.
Taiwan's health authorities have uncovered the illegal use of maleic acid as a food additive in products from two factories, seizing an estimated 25 tonnes of product and ingredients before they could reach the market.
Maleic acid was added to products including tapioca balls and rice noodles to give them more elasticity. A health official said maleic acid is not known to have adverse effects on human health, and has not been linked to cancer, adding that an average-sized adult could consume 30mg of maleic acid in a day without their health being affected.
Health authorities were alerted in March and April that certain food manufacturers have been adding maleic acid to their products and launched an investigation into the tip-offs.
After the seizure, concentrations of maleic acid of under 800ppm was found in the food, an amount deemed within a safe range. A doctor specializing in clinical toxicology at Chang Gung Memorial Hospital in New Taipei, said maleic acid is a poisonous industrial chemical and it is therefore unethical to add it to food, even in small amounts.
The authorities will conduct a further investigation into the manufacturers involved and decide whether to issue a fine of NT$30,000 to NT$150,000 (US$1,000-$5,000).
Maleic acid is not allowed to add in food, we should learn some safe information about the compound, and be minder of the food which is added Maleic acid.
Want to learn more information about Orthoboric acid, you can access the guidechem.com. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.
Maleic acid is not very important economically, since the anhydride is easier to use. It is employed in the manufacture of phthalic-type alkyd and polyester resins, surface coatings, copolymers, plasticizers, lubricant additives and agricultural chemicals; in adhesives and sealants; as a preservative for oils and fats; organic synthesis; dyeing and finishing wool, cotton and silk; and preparing the maleate salts of antihistamines and similar drugs.
Maleic acid(CAS NO:110-16-7) is not a kind of food additives, but some unscrupulous manufacturers ued Maleic acid in some food. Here is a case about Maleic acid used as food additive in Taiwan.
Taiwan's health authorities have uncovered the illegal use of maleic acid as a food additive in products from two factories, seizing an estimated 25 tonnes of product and ingredients before they could reach the market.
Maleic acid was added to products including tapioca balls and rice noodles to give them more elasticity. A health official said maleic acid is not known to have adverse effects on human health, and has not been linked to cancer, adding that an average-sized adult could consume 30mg of maleic acid in a day without their health being affected.
Health authorities were alerted in March and April that certain food manufacturers have been adding maleic acid to their products and launched an investigation into the tip-offs.
After the seizure, concentrations of maleic acid of under 800ppm was found in the food, an amount deemed within a safe range. A doctor specializing in clinical toxicology at Chang Gung Memorial Hospital in New Taipei, said maleic acid is a poisonous industrial chemical and it is therefore unethical to add it to food, even in small amounts.
The authorities will conduct a further investigation into the manufacturers involved and decide whether to issue a fine of NT$30,000 to NT$150,000 (US$1,000-$5,000).
Maleic acid is not allowed to add in food, we should learn some safe information about the compound, and be minder of the food which is added Maleic acid.
Want to learn more information about Orthoboric acid, you can access the guidechem.com. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.
2014年1月16日星期四
The Environmental Assessment of Diflubenzuron
Diflubenzuron is a kind of colorless to yellow crystals, the Density is 1.56, Melting Point is 230-232 C, we should store it in the temperaure of 0-6 C.The Molecular Formula is C14H9ClF2N2O2, Molecular Weight is 310.683, and the CAS Registry Number is 35367-38-5.
Diflubenzuron is a benzoylurea-type insecticide of the benzamide class. It is used in forest management and on field crops to selectively control insect pests, particularly forest tent caterpillar moths, boll weevils, gypsy moths, and other types of moths. The mechanism of action of diflubenzuron involves inhibiting the production of chitin which is used by an insect to build its exoskeleton.
Diflubenzuron(CAS NO: 35367-38-5) appears to be relatively non-persistent and immobile under normal use conditions. The major route of dissipation appears to be biotic processes (half-life of approximately 2 days for aerobic soil metabolism). Diflubenzuron is stable to hydrolysis and photolysis.
Available data indicate that it is unlikely that diflubenzuron will contaminate ground water or surface water. Additional data are needed to confirm this conclusion.One of the metabolites of diflubenzuron, 4-chloroaniline, has been classified by the United States Environmental Protection Agency as a probable human carcinogen.
Diflubenzuron is practically non-toxic to avian species, small mammals, freshwater fish and marine/estuarine fish on an acute oral dietary basis, while it is slightly toxic to avian species on a subacute dietary basis.
Diflubenzuron is non-toxic to bees. The results indicate that diflubenzuron is very highly toxic to freshwater aquatic invertebrates, including marine/estuarine crustacea, while it is highly toxic to marine/estuarine mollusks. The results indicate that diflubenzuron affects reproduction, growth and survival in freshwater invertebrates as well as reproduction in marine/estuarine invertebrates.
The risk assessment conducted using available data indicates that levels of concern are not exceeded for avian species, mammals, insects or freshwater fish. Although the use of diflubenzuron is expected to cause some adverse chronic effects to estuarine/marine fish at the highest application rate (forestry), these effects are not as widespread as those associated with freshwater and estuarine/marine invertebrates.
The use of diflubenzuron is expected to cause adverse acute and chronic effects to both freshwater and estuarine/marine invertebrates, including endangered species. The risk to aquatic invertebrates is also expected to be substantial when diflubenzuron is applied to control mosquito larvae. Since this use involves direct application to water and/or near water, no mitigation is currently proposed.
Want to learn more information about Diflubenzuron, you can access the guidechem.com. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.
Diflubenzuron is a benzoylurea-type insecticide of the benzamide class. It is used in forest management and on field crops to selectively control insect pests, particularly forest tent caterpillar moths, boll weevils, gypsy moths, and other types of moths. The mechanism of action of diflubenzuron involves inhibiting the production of chitin which is used by an insect to build its exoskeleton.
Diflubenzuron(CAS NO: 35367-38-5) appears to be relatively non-persistent and immobile under normal use conditions. The major route of dissipation appears to be biotic processes (half-life of approximately 2 days for aerobic soil metabolism). Diflubenzuron is stable to hydrolysis and photolysis.
Available data indicate that it is unlikely that diflubenzuron will contaminate ground water or surface water. Additional data are needed to confirm this conclusion.One of the metabolites of diflubenzuron, 4-chloroaniline, has been classified by the United States Environmental Protection Agency as a probable human carcinogen.
Diflubenzuron is practically non-toxic to avian species, small mammals, freshwater fish and marine/estuarine fish on an acute oral dietary basis, while it is slightly toxic to avian species on a subacute dietary basis.
Diflubenzuron is non-toxic to bees. The results indicate that diflubenzuron is very highly toxic to freshwater aquatic invertebrates, including marine/estuarine crustacea, while it is highly toxic to marine/estuarine mollusks. The results indicate that diflubenzuron affects reproduction, growth and survival in freshwater invertebrates as well as reproduction in marine/estuarine invertebrates.
The risk assessment conducted using available data indicates that levels of concern are not exceeded for avian species, mammals, insects or freshwater fish. Although the use of diflubenzuron is expected to cause some adverse chronic effects to estuarine/marine fish at the highest application rate (forestry), these effects are not as widespread as those associated with freshwater and estuarine/marine invertebrates.
The use of diflubenzuron is expected to cause adverse acute and chronic effects to both freshwater and estuarine/marine invertebrates, including endangered species. The risk to aquatic invertebrates is also expected to be substantial when diflubenzuron is applied to control mosquito larvae. Since this use involves direct application to water and/or near water, no mitigation is currently proposed.
Want to learn more information about Diflubenzuron, you can access the guidechem.com. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.
2014年1月15日星期三
Talking something about Chromium picolinate
Chromium picolinate is a violet-red crystalline powder with the Molecular Formula: C18H12CrN3O6 and Molecular Weight: 418.30048. It is a chemical compound sold as a nutritional supplement to prevent or treat chromium deficiency, although its mechanisms of action in the body and the amounts needed for optimal health are not well defined. The CAS Registry Number of Chromium picolinate is 14639-25-9.
In 1959, Chromium picolinate was first identified as an element that enables the hormone insulin to function properly. Since then, it has been studied for diabetes and has become a popular dietary supplement. It is widely available in health food stores, drug stores and online.
Chromium picolinate(CAS NO:14639-25-9) is believed to help the body process carbohydrates and fats. It is marketed as a weight loss aid for dieters and an ergogenic aid for bodybuilders and athletes. No adverse events have been consistently and frequently reported with short-term chromium use in human studies. For this reason, the Institute of Medicine has not set a recommended upper limit for this medicine.
Chromium has long been of interest for its possible connection to various health conditions. Among the most active areas of chromium research are its use in supplement form to treat diabetes, lower blood lipid levels, promote weight loss, and improve body composition.
There are reports of significant age-related decreases in the Chromium picolinate concentrations of hair, sweat and blood, which might suggest that older people are more vulnerable to it depletion than younger adults. One cannot be sure, however, as Chromium picolinate status is difficult to determine. That's because blood, urine, and hair levels do not necessarily reflect body stores. Furthermore, no chromium-specific enzyme or other biochemical marker has been found to reliably assess a person's chromium status.
There is considerable interest in the possibility that supplemental chromium may help to treat impaired glucose tolerance and type 2 diabetes, but the research to date is inconclusive. No large, randomized, controlled clinical trials testing this hypothesis have been reported in the United States. Nevertheless, this is an active area of research.
Absorption of Chromium picolinate from the intestinal tract is low, ranging from less than 0.4% to 2.5% of the amount consumed, and the remainder is excreted in the feces. Enhancing the mineral's absorption are vitamin C (found in fruits and vegetables and their juices) and the B vitamin niacin (found in meats, poultry, fish, and grain products) . Absorbed Chromium picolinate is stored in the liver, spleen, soft tissue, and bone .
If you need take Chromium picolinate, you should pay more attention to it. Learning more health information, properties or suppliers about Chromium picolinate, you can access Guidechem. Guidechem Chemical Network providing the most complete information of the chemical industry.
In 1959, Chromium picolinate was first identified as an element that enables the hormone insulin to function properly. Since then, it has been studied for diabetes and has become a popular dietary supplement. It is widely available in health food stores, drug stores and online.
Chromium picolinate(CAS NO:14639-25-9) is believed to help the body process carbohydrates and fats. It is marketed as a weight loss aid for dieters and an ergogenic aid for bodybuilders and athletes. No adverse events have been consistently and frequently reported with short-term chromium use in human studies. For this reason, the Institute of Medicine has not set a recommended upper limit for this medicine.
Chromium has long been of interest for its possible connection to various health conditions. Among the most active areas of chromium research are its use in supplement form to treat diabetes, lower blood lipid levels, promote weight loss, and improve body composition.
There are reports of significant age-related decreases in the Chromium picolinate concentrations of hair, sweat and blood, which might suggest that older people are more vulnerable to it depletion than younger adults. One cannot be sure, however, as Chromium picolinate status is difficult to determine. That's because blood, urine, and hair levels do not necessarily reflect body stores. Furthermore, no chromium-specific enzyme or other biochemical marker has been found to reliably assess a person's chromium status.
There is considerable interest in the possibility that supplemental chromium may help to treat impaired glucose tolerance and type 2 diabetes, but the research to date is inconclusive. No large, randomized, controlled clinical trials testing this hypothesis have been reported in the United States. Nevertheless, this is an active area of research.
Absorption of Chromium picolinate from the intestinal tract is low, ranging from less than 0.4% to 2.5% of the amount consumed, and the remainder is excreted in the feces. Enhancing the mineral's absorption are vitamin C (found in fruits and vegetables and their juices) and the B vitamin niacin (found in meats, poultry, fish, and grain products) . Absorbed Chromium picolinate is stored in the liver, spleen, soft tissue, and bone .
If you need take Chromium picolinate, you should pay more attention to it. Learning more health information, properties or suppliers about Chromium picolinate, you can access Guidechem. Guidechem Chemical Network providing the most complete information of the chemical industry.
2014年1月14日星期二
Clinical studies on the usages of DL-Phenylalanine
Phenylalanine, which is an alpha (essential) amino acid, it is white powder with the Molecular Formula:C9H11NO2 and Molecular Weight:165.19. It is stable in and incompatible with strong oxidizing agents. The CAS Registry Number is 150-30-1. It is found in both naturally occurring (L-phenylalanine) and artificially synthesized (D-phenylalanine) forms.
The two different forms of phenylalanine have different medical applications, and the derived DL form has the properties of both, and is, as such, used in the treatment of a number of conditions. As with all phenylalanine, DL-phenylalanine should not be consumed by people with phenylketonuria, a disease which causes the body to be unable to use phenylalanine.
DL-Phenylalanine(CAS NO:150-30-1) is used in the manufacture of food and drink products and sold as a nutritional supplement for its reputed analgesic and antidepressant effects. It is a direct precursor to the neuromodulator phenylethylamine, a commonly used dietary supplement. But in this article I will show you medicial use of this compound.
D-phenylalanine (but not L-phenylalanine) has been proposed to treat chronic pain, but so far the studies have not shown good evidence that it works. Two studies that appeared to show positive results had flaws that made the findings unreliable. Other clinical studies have found it to be no more effective than placebo in reducing pain. No randomized controlled trials have been done in the past 20 years to study any possible benefit of taking it for chronic pain, so more research is needed to determine its safety and effectiveness.
Some clinical studies suggest that DL-Phenylalanine may be helpful as part of a comprehensive therapy for depression. However, most of the studies were done in the 1970s and 1980s and were not rigorously tested. People have reported that their mood improved when they took this compound. Researchers think this is because it increases production of brain chemicals, such as dopamine and norepinephrine. More research is needed to tell whether phenylalanine has any real effect on depression.
Some preliminary studies have found that L-phenylalanine strengthens the effect of UVA radiation for people with vitiligo. Vitiligo is a condition where irregular depigmentation causes white patches of skin. It may lead to some darkening or repigmentation of the white patches, particularly on the face. However, more research is needed to see whether this compound is truly effective.
One animal study suggests that D-phenylalanine may improve rigidity, walking disabilities, speech difficulties, and depression associated with Parkinson's disease. However, there is no evidence yet whether D-phenylalanine would have the same effect in humans.
Want to learn more information about DL-Phenylalanine, you can access the guidechem.com. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
The two different forms of phenylalanine have different medical applications, and the derived DL form has the properties of both, and is, as such, used in the treatment of a number of conditions. As with all phenylalanine, DL-phenylalanine should not be consumed by people with phenylketonuria, a disease which causes the body to be unable to use phenylalanine.
DL-Phenylalanine(CAS NO:150-30-1) is used in the manufacture of food and drink products and sold as a nutritional supplement for its reputed analgesic and antidepressant effects. It is a direct precursor to the neuromodulator phenylethylamine, a commonly used dietary supplement. But in this article I will show you medicial use of this compound.
D-phenylalanine (but not L-phenylalanine) has been proposed to treat chronic pain, but so far the studies have not shown good evidence that it works. Two studies that appeared to show positive results had flaws that made the findings unreliable. Other clinical studies have found it to be no more effective than placebo in reducing pain. No randomized controlled trials have been done in the past 20 years to study any possible benefit of taking it for chronic pain, so more research is needed to determine its safety and effectiveness.
Some clinical studies suggest that DL-Phenylalanine may be helpful as part of a comprehensive therapy for depression. However, most of the studies were done in the 1970s and 1980s and were not rigorously tested. People have reported that their mood improved when they took this compound. Researchers think this is because it increases production of brain chemicals, such as dopamine and norepinephrine. More research is needed to tell whether phenylalanine has any real effect on depression.
Some preliminary studies have found that L-phenylalanine strengthens the effect of UVA radiation for people with vitiligo. Vitiligo is a condition where irregular depigmentation causes white patches of skin. It may lead to some darkening or repigmentation of the white patches, particularly on the face. However, more research is needed to see whether this compound is truly effective.
One animal study suggests that D-phenylalanine may improve rigidity, walking disabilities, speech difficulties, and depression associated with Parkinson's disease. However, there is no evidence yet whether D-phenylalanine would have the same effect in humans.
Want to learn more information about DL-Phenylalanine, you can access the guidechem.com. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
2014年1月13日星期一
The main usages of Ceftiofur sodium
Ceftiofur Sodium is a off-white or yellowish crystalline powder, the Molecular Formula is C19H16N5NaO7S3, Molecular Weight is 523.56258, and CAS NO is 104010-37-9. It is a broad spectrum cephalosporin antibiotic active against gram positive and negative bacteria. It has a broad range of in vitro activity against a variety of pathogens, including many species of Pasturella, Streptococcus, Staphylococcus, Salmonella, and E.coli.
In this article, I will show you the section usages of Ceftiofur sodium, indicataed for treatment of Cattle, Swine and Sheep.
Used in Cattle
Ceftiofur Sodium(CAS NO: 104010-37-9) is indicated for treatment of bovine respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. It is also indicated for treatment of acute bovine interdigital necrobacillosis associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.
Administer to cattle by intramuscular or subcutaneous injection at the dosage of 0.5 to 1.0 mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight (1-2 mL reconstituted sterile solution per 100 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments. Selection of dosage (0.5 to 1.0 mg/lb) should be based on the practitioner's judgment of severity of disease.
Used in Swine
Ceftiofur Sodium is also indicated for treatment/control of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus pleuropneumoniae,Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis.
Administer to swine by intramuscular injection at the dosage of 1.36 to 2.27 mg ceftiofur per pound (3.0 to 5.0 mg/kg) of body weight (1 mL of reconstituted sterile solution per 22 to 37 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days.
Used in Sheep
Ceftiofur Sodium is indicated for treatment of sheep respiratory disease (sheep pneumonia) associated with Mannheimia haemolytica and Pasteurella multocida.
Administer to sheep by intramuscular injection at the dosage of 0.5 to 1.0 mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight (1-2 mL reconstituted sterile solution per 100 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments. Selection of dosage (0.5 to 1.0 mg/lb) should be based on the practitioner's judgment of severity of disease.
Want to learn more information about Ceftiofur sodium, you can access the guidechem.com.
In this article, I will show you the section usages of Ceftiofur sodium, indicataed for treatment of Cattle, Swine and Sheep.
Used in Cattle
Ceftiofur Sodium(CAS NO: 104010-37-9) is indicated for treatment of bovine respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. It is also indicated for treatment of acute bovine interdigital necrobacillosis associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.
Administer to cattle by intramuscular or subcutaneous injection at the dosage of 0.5 to 1.0 mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight (1-2 mL reconstituted sterile solution per 100 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments. Selection of dosage (0.5 to 1.0 mg/lb) should be based on the practitioner's judgment of severity of disease.
Used in Swine
Ceftiofur Sodium is also indicated for treatment/control of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus pleuropneumoniae,Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis.
Administer to swine by intramuscular injection at the dosage of 1.36 to 2.27 mg ceftiofur per pound (3.0 to 5.0 mg/kg) of body weight (1 mL of reconstituted sterile solution per 22 to 37 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days.
Used in Sheep
Ceftiofur Sodium is indicated for treatment of sheep respiratory disease (sheep pneumonia) associated with Mannheimia haemolytica and Pasteurella multocida.
Administer to sheep by intramuscular injection at the dosage of 0.5 to 1.0 mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight (1-2 mL reconstituted sterile solution per 100 lbs body weight). Treatment should be repeated at 24-hour intervals for a total of three consecutive days. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments. Selection of dosage (0.5 to 1.0 mg/lb) should be based on the practitioner's judgment of severity of disease.
Want to learn more information about Ceftiofur sodium, you can access the guidechem.com.
2014年1月12日星期日
General information about Methyl disulfide
Methyl disulfide is an organic chemical compound with the molecular formula CH3SSCH3 which is the simplest disulfide. It is of Slightly yellow transparent liquid, there is stench flavor, insoluble in water, easily soluble in acetic acid, ethanol. The CAS NO is 624-92-0.
Methyl disulfide is used as activator of hydrogen desulfurization and precuring process in refining petroleum refining; it may used as cracking, coking inhibitor in petrochemical; it also used as solvent and pesticide intermediate.
The uses of Methyl disulfide(CSA NO: 624-92-0) in the industry are many and vaired according to the application it is used in. It is used in the preparation of Para (methylthio) phenol which is the title compound used in the production of various pesticides by reacting the Methyl disulfide and chlorine with borontriflouride phenolate. Thiophene and Methyl disulfide are blended with combustible hydrocarbon fuel gas to impart a gassy odor to the fuel gas. Methyl disulfide is used in each of these patents as a sulfiding reagent to control catalyst activity.
Despite its use in a wide variety of industrially important thermochemical processes, little is known about the thermal decomposition mechanism of dimethyl disulfide. To obtain more insight, the radical decomposition mechanism of Methyl disulfide is studied theoretically and a kinetic model is developed accounting for the formation of all the decomposition products observed in the experimental studies available in literature.
First aid measures
General advice : Move out of dangerous area. Consult a physician. Show this material safety data sheet to the doctor in attendance. Material may produce a serious, potentially fatal pneumonia if swallowed or vomited.
If inhaled : Call a physician or poison control center immediately. If unconscious place in recovery position and seek medical advice.
In case of skin contact : If on skin, rinse well with water. If on clothes, remove clothes.
In case of eye contact : Immediately flush eye(s) with plenty of water. Remove contact lenses. Protect unharmed eye. Keep eye wide open while rinsing. If eye irritation persists, consult a specialist.
If swallowed : Keep respiratory tract clear. Never give anything by mouth to an unconscious person. If symptoms persist, call a physician. Take victim immediately to hospital.
Suppliers of in Methyl disulfide in Guidechem
1.Wuhan Fortuna Chemical Co., Ltd.
Methyl disulfide
Updatetime:Jan 10 2014
Purity:98% Min. Order:25/Kilogram Supply Ability:1000 Month/Kilogram
Tel:0086-27-59207850
Address:A2705,Dong Yi Shi Qu,129 XinHua Road
2.Capot Chemical Co., Ltd.
Methyl disulfide
Updatetime:Jan 10 2014
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road
3.AOPHARM
Methyl disulfide
Updatetime:Jan 10 2014
Purity:99%
DetailDesc:Colorless to yellowish liquid
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd
Want to find more suppliers information about Methyl disulfide or any other chemicals, you can access the guidechem.com.
Methyl disulfide is used as activator of hydrogen desulfurization and precuring process in refining petroleum refining; it may used as cracking, coking inhibitor in petrochemical; it also used as solvent and pesticide intermediate.
The uses of Methyl disulfide(CSA NO: 624-92-0) in the industry are many and vaired according to the application it is used in. It is used in the preparation of Para (methylthio) phenol which is the title compound used in the production of various pesticides by reacting the Methyl disulfide and chlorine with borontriflouride phenolate. Thiophene and Methyl disulfide are blended with combustible hydrocarbon fuel gas to impart a gassy odor to the fuel gas. Methyl disulfide is used in each of these patents as a sulfiding reagent to control catalyst activity.
Despite its use in a wide variety of industrially important thermochemical processes, little is known about the thermal decomposition mechanism of dimethyl disulfide. To obtain more insight, the radical decomposition mechanism of Methyl disulfide is studied theoretically and a kinetic model is developed accounting for the formation of all the decomposition products observed in the experimental studies available in literature.
First aid measures
General advice : Move out of dangerous area. Consult a physician. Show this material safety data sheet to the doctor in attendance. Material may produce a serious, potentially fatal pneumonia if swallowed or vomited.
If inhaled : Call a physician or poison control center immediately. If unconscious place in recovery position and seek medical advice.
In case of skin contact : If on skin, rinse well with water. If on clothes, remove clothes.
In case of eye contact : Immediately flush eye(s) with plenty of water. Remove contact lenses. Protect unharmed eye. Keep eye wide open while rinsing. If eye irritation persists, consult a specialist.
If swallowed : Keep respiratory tract clear. Never give anything by mouth to an unconscious person. If symptoms persist, call a physician. Take victim immediately to hospital.
Suppliers of in Methyl disulfide in Guidechem
1.Wuhan Fortuna Chemical Co., Ltd.
Methyl disulfide
Updatetime:Jan 10 2014
Purity:98% Min. Order:25/Kilogram Supply Ability:1000 Month/Kilogram
Tel:0086-27-59207850
Address:A2705,Dong Yi Shi Qu,129 XinHua Road
2.Capot Chemical Co., Ltd.
Methyl disulfide
Updatetime:Jan 10 2014
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road
3.AOPHARM
Methyl disulfide
Updatetime:Jan 10 2014
Purity:99%
DetailDesc:Colorless to yellowish liquid
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd
Want to find more suppliers information about Methyl disulfide or any other chemicals, you can access the guidechem.com.
2014年1月10日星期五
Complete information about 5-Amino-1H-tetrazole hydrate
Formula : CH3N5
Weight: 85.07
Appearance:white crystals
Stability:Stable under normal temperatures and pressures.
Storage Temperature:Keep container closed when not in use. Store in a tightly closed container. Keep container closed to prevent drying out. Material can explode if dry.
EINECS Number: 224-581-7
CAS No. : 4418-61-5
Related Categories: Miscellaneous; pharmacetical; Building Blocks; Heterocyclic Building Blocks; Tetrazoles; pharmaceutical intermediates ; organic synthesis intermediates ; chemical additive; nitrogen compounds
5-Amino-1H-tetrazole hydrate is mainly used for organic synthesis intermediates, electronic cleaners, automotive airbags, electronic products. 5-Amino-1H-tetrazole hydrate (CAS NO: 4418-61-5) can be used as raw material to take a variety of performance very excellent energetic materials. Fillers for automobile airbags in the pharmaceutical and chemical synthesis is also used in medicine, as well as high-energy synthesis of organic compounds; reagents used on the organic ligand, with its direct and metal complex.
We should learn something safe information about 5-Amino-1H-tetrazole hydrate.
1.First aid measures:
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the
upper and lower lids.
Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do NOT induce vomiting. Allow the victim to rinse his mouth and then to drink 2-4 cupfuls of water, and seek medical advice.
Inhalation: Remove from exposure to fresh air immediately.
Notes to Physician: Treat symptomatically and supportively.
2.Personal Protective Equipment
Eyes: Wear safety glasses and chemical goggles if splashing is possible.
Skin: Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline
respirator in the positive pressure mode with emergency escape provisions.
5-Amino-1H-tetrazole hydrate is an important compound, our Guidechem can provide high quality chemicals , I hope these information can help you!
1.Wuhan Fortuna Chemical Co., Ltd.
Updatetime:Jan 10 2014
Purity:99%min Min. Order: Supply Ability:avaiable stock
DetailDesc:5-Aminotetrazole
Tel:0086-27-59207850
Address:A2705,Dong Yi Shi Qu,129# XinHua Road
2.Hangzhou Dayangchem Co., Ltd.
Updatetime:Jan 10 2014
DetailDesc:5-Aminoterazole
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China
3.Jinan Haohua Industry Co., Ltd.
5-Amino-1H-tetrazole hydrate
Updatetime:Jan 10 2014
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Haohua Industry has set up four big production bases and one R&D Center in China. Over the past years, we are engaged in the exporting business, our products have reached far to the USA, Europe, South Asia, Middle East and so on, also our company has established long term .
Tel:0086-531-58773055
Address:No.59 Gongye South RD
4.Shanghai UCHEM Inc.
5-Amino-1H-tetrazole hydrate
Updatetime:Jan 10 2014
DetailDesc:5-Amino-1H-tetrazole
Tel:086-021-61555264
Address:4th Floor,Build A,500Jianyun Road,Zhoupu,Pudong,Shanghai
5.Nanjing Chemlin Chemical Co., Ltd.
5-Amino-1H-tetrazole hydrate
Updatetime:Jan 09 2014
Purity:99%
DetailDesc:5-Aminotetrazole
Tel:86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Want to learn more information about 5-Amino-1H-tetrazole hydrate, you can access the guidechem.com.
Weight: 85.07
Appearance:white crystals
Stability:Stable under normal temperatures and pressures.
Storage Temperature:Keep container closed when not in use. Store in a tightly closed container. Keep container closed to prevent drying out. Material can explode if dry.
EINECS Number: 224-581-7
CAS No. : 4418-61-5
Related Categories: Miscellaneous; pharmacetical; Building Blocks; Heterocyclic Building Blocks; Tetrazoles; pharmaceutical intermediates ; organic synthesis intermediates ; chemical additive; nitrogen compounds
5-Amino-1H-tetrazole hydrate is mainly used for organic synthesis intermediates, electronic cleaners, automotive airbags, electronic products. 5-Amino-1H-tetrazole hydrate (CAS NO: 4418-61-5) can be used as raw material to take a variety of performance very excellent energetic materials. Fillers for automobile airbags in the pharmaceutical and chemical synthesis is also used in medicine, as well as high-energy synthesis of organic compounds; reagents used on the organic ligand, with its direct and metal complex.
We should learn something safe information about 5-Amino-1H-tetrazole hydrate.
1.First aid measures:
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the
upper and lower lids.
Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do NOT induce vomiting. Allow the victim to rinse his mouth and then to drink 2-4 cupfuls of water, and seek medical advice.
Inhalation: Remove from exposure to fresh air immediately.
Notes to Physician: Treat symptomatically and supportively.
2.Personal Protective Equipment
Eyes: Wear safety glasses and chemical goggles if splashing is possible.
Skin: Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline
respirator in the positive pressure mode with emergency escape provisions.
5-Amino-1H-tetrazole hydrate is an important compound, our Guidechem can provide high quality chemicals , I hope these information can help you!
1.Wuhan Fortuna Chemical Co., Ltd.
Updatetime:Jan 10 2014
Purity:99%min Min. Order: Supply Ability:avaiable stock
DetailDesc:5-Aminotetrazole
Tel:0086-27-59207850
Address:A2705,Dong Yi Shi Qu,129# XinHua Road
2.Hangzhou Dayangchem Co., Ltd.
Updatetime:Jan 10 2014
DetailDesc:5-Aminoterazole
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China
3.Jinan Haohua Industry Co., Ltd.
5-Amino-1H-tetrazole hydrate
Updatetime:Jan 10 2014
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Haohua Industry has set up four big production bases and one R&D Center in China. Over the past years, we are engaged in the exporting business, our products have reached far to the USA, Europe, South Asia, Middle East and so on, also our company has established long term .
Tel:0086-531-58773055
Address:No.59 Gongye South RD
4.Shanghai UCHEM Inc.
5-Amino-1H-tetrazole hydrate
Updatetime:Jan 10 2014
DetailDesc:5-Amino-1H-tetrazole
Tel:086-021-61555264
Address:4th Floor,Build A,500Jianyun Road,Zhoupu,Pudong,Shanghai
5.Nanjing Chemlin Chemical Co., Ltd.
5-Amino-1H-tetrazole hydrate
Updatetime:Jan 09 2014
Purity:99%
DetailDesc:5-Aminotetrazole
Tel:86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Want to learn more information about 5-Amino-1H-tetrazole hydrate, you can access the guidechem.com.
2014年1月9日星期四
Astragaloside IV has so many benefits
Astragaloside IV, the main component of the traditional Chinese medicine astragalus membra-naceus, has been shown to inhibit inflammation, oxidation, and apoptosis, and exerts immu-noregulatory effects.
Astragaloside IV is one of the main active compounds of Astragalus membranaceus Bunge. Experimental studies from several laboratories,have provided abundant evidence demonstrating the explicit cardiovascular-protective effects of Astragaloside IV(CAS NO:84687-43-4).
Now, let’s talk about what can we benefit from Astragaloside IV in detail.
1.Immunostimulant: acting through a number of different pathways, especially,by increasing the number of stem cells in the spinal cord and lymphatic tissue and encouraging them to develop into active immune cells or stimulating production of immunoglobulins and macrophages.
2.Neuroprotective: in traditional Chinese medicine, astragalus root extract is used to treat neurodegenerative diseases. One study demonstrated the capacity of astragaloside IV(CAS NO:84687-43-4) to protect dopaminergic neurons (progressive degeneration of dopaminergic neurons leads to the development of Parkinson's disease).
3.Antibacterial: as demonstrated by in vitro studies on Shigella dysenteriae, Streptococcus haemolyticus, Diplococcus pneumoniae and Staphylococcus aureus.
4.Antiviral: inhibiting replication of certain viruses such as coxsackie, responsible for myocarditis (inflammation of the heart muscle). In both animal and human studies, they were shown to stimulate endogenous interferon production and to maximise its effect on viral infections.
5.Anti-inflammatory: as shown in certain animal models. The ability of astragaloside IV to stem inflammation of the airways in chronic asthma has been reported in studies on mice.
6.Inhibitory: against formation of the AGEs involved in neuropathic complications of diabetes.
7.Protective: against the toxic effects of chemotherapy. Astragalus extract boosts resistance to the immunosuppressive effects of chemotherapy drugs by encouraging macrophages to product interleukin 6 and tumour necrosis factor.
8.Antioxidant: inhibiting lipid peroxidation by 40% in vitro. These antioxidant properties may go some way to explaining the cardio- and neuro-protective effects of astragalus and astragaloside IV.
9.Cardioprotective: with studies highlighting health benefits for patients with congestive cardiac insufficiency and angina pectoris. Astragalus extracts have a cardiotonic effect.
With so many beneficial properties, particularly immunostimulant, anti-inflammatory, antioxidant and anti-glycation, Astragaloside IV is a truly essential anti-aging supplement. Its exceptional properties are due to Astragaloside IV specific ability to activate telomerase, thus slowing down the shortening of telomeres, and extending cell lifespan. Shortening of telomers is associated with cellular ageing and the development of age-related diseases.
Want to learn information about Astragaloside IV, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
Astragaloside IV is one of the main active compounds of Astragalus membranaceus Bunge. Experimental studies from several laboratories,have provided abundant evidence demonstrating the explicit cardiovascular-protective effects of Astragaloside IV(CAS NO:84687-43-4).
Now, let’s talk about what can we benefit from Astragaloside IV in detail.
1.Immunostimulant: acting through a number of different pathways, especially,by increasing the number of stem cells in the spinal cord and lymphatic tissue and encouraging them to develop into active immune cells or stimulating production of immunoglobulins and macrophages.
2.Neuroprotective: in traditional Chinese medicine, astragalus root extract is used to treat neurodegenerative diseases. One study demonstrated the capacity of astragaloside IV(CAS NO:84687-43-4) to protect dopaminergic neurons (progressive degeneration of dopaminergic neurons leads to the development of Parkinson's disease).
3.Antibacterial: as demonstrated by in vitro studies on Shigella dysenteriae, Streptococcus haemolyticus, Diplococcus pneumoniae and Staphylococcus aureus.
4.Antiviral: inhibiting replication of certain viruses such as coxsackie, responsible for myocarditis (inflammation of the heart muscle). In both animal and human studies, they were shown to stimulate endogenous interferon production and to maximise its effect on viral infections.
5.Anti-inflammatory: as shown in certain animal models. The ability of astragaloside IV to stem inflammation of the airways in chronic asthma has been reported in studies on mice.
6.Inhibitory: against formation of the AGEs involved in neuropathic complications of diabetes.
7.Protective: against the toxic effects of chemotherapy. Astragalus extract boosts resistance to the immunosuppressive effects of chemotherapy drugs by encouraging macrophages to product interleukin 6 and tumour necrosis factor.
8.Antioxidant: inhibiting lipid peroxidation by 40% in vitro. These antioxidant properties may go some way to explaining the cardio- and neuro-protective effects of astragalus and astragaloside IV.
9.Cardioprotective: with studies highlighting health benefits for patients with congestive cardiac insufficiency and angina pectoris. Astragalus extracts have a cardiotonic effect.
With so many beneficial properties, particularly immunostimulant, anti-inflammatory, antioxidant and anti-glycation, Astragaloside IV is a truly essential anti-aging supplement. Its exceptional properties are due to Astragaloside IV specific ability to activate telomerase, thus slowing down the shortening of telomeres, and extending cell lifespan. Shortening of telomers is associated with cellular ageing and the development of age-related diseases.
Want to learn information about Astragaloside IV, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
2014年1月8日星期三
A report on Chromic acid
A man who fell into a barrel of Chromic acid while at work Monday followed correct procedures and is recovering in a Grand Rapids, Mich., hospital, his employer said.
The man, 45, is a 10-year employee of Lacks Enterprises in Grand Rapids and was performing a maintenance function when he slipped and fell into a tank of diluted chromic acid(CAS: 7738-94-5), a toxic and carcinogenic element of the chrome-plating process, the news website MLive.com reported Monday.
It added only the man's legs were dunked in the acid.Jim Green, human resources director of the firm, said the employee was wearing a safety harness and other appropriate equipment when the accident occurred, and fellow employees hosed the victim down according to protocol.
"I spoke to him personally today, and hope to be in touch with him again soon. We anticipate a full recovery," Green said of the employee's injuries.
Chromic acid(CAS:7738-94-5)was widely used in the instrument repair industry, due to its ability to "brighten" raw brass. A chromic acid dip leaves behind a bright yellow patina on the brass. Due to growing health and environmental concerns, many have discontinued use of this chemical in their repair shops.
In this article, we can talk something about the Potential Health Effects of chromic acid.
Inhalation: Corrosive. Extremely destructive to tissues of the mucous membranes and upper respiratory tract. May cause ulceration and perforation of the nasal septum. Symptoms may include sore throat, coughing, shortness of breath, and labored breathing. May produce pulmonary sensitization or allergic asthma. Higher exposures may cause pulmonary edema.
Ingestion: Corrosive. Swallowing can cause severe burns of the mouth, throat, and stomach, leading to death. Can cause sore throat, vomiting, diarrhea. May cause violent gastroenteritis, peripheral vascular collapse, dizziness, intense thirst, muscle cramps, shock, coma, abnormal bleeding, fever, liver damage and acute renal failure.
Skin Contact: Corrosive. Symptoms of redness, pain, and severe burn can occur. Dusts and strong solutions may cause severe irritation. Contact with broken skin may cause ulcers (chrome sores) and absorption, which may cause systemic poisoning, affecting kidney and liver functions. May cause skin sensitization.
Eye Contact: Corrosive. Contact can cause blurred vision, redness, pain and severe tissue burns. May cause corneal injury or blindness.
Chromic acid Exposure: Repeated or prolonged exposure can cause ulceration and perforation of the nasal septum, respiratory irritation, liver and kidney damage and ulceration of the skin. Ulcerations at first may be painless, but may penetrate to the bone producing "chrome holes." Known to be a human carcinogen.
Aggravation of Pre-existing Conditions: Persons with pre-existing skin disorders, asthma, allergies or known sensitization to chromic acid or chromates may be more susceptible to the effects of this material.
Want to learn more information about Chromic acid, you can access the guidechem.com. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
The man, 45, is a 10-year employee of Lacks Enterprises in Grand Rapids and was performing a maintenance function when he slipped and fell into a tank of diluted chromic acid(CAS: 7738-94-5), a toxic and carcinogenic element of the chrome-plating process, the news website MLive.com reported Monday.
It added only the man's legs were dunked in the acid.Jim Green, human resources director of the firm, said the employee was wearing a safety harness and other appropriate equipment when the accident occurred, and fellow employees hosed the victim down according to protocol.
"I spoke to him personally today, and hope to be in touch with him again soon. We anticipate a full recovery," Green said of the employee's injuries.
Chromic acid(CAS:7738-94-5)was widely used in the instrument repair industry, due to its ability to "brighten" raw brass. A chromic acid dip leaves behind a bright yellow patina on the brass. Due to growing health and environmental concerns, many have discontinued use of this chemical in their repair shops.
In this article, we can talk something about the Potential Health Effects of chromic acid.
Inhalation: Corrosive. Extremely destructive to tissues of the mucous membranes and upper respiratory tract. May cause ulceration and perforation of the nasal septum. Symptoms may include sore throat, coughing, shortness of breath, and labored breathing. May produce pulmonary sensitization or allergic asthma. Higher exposures may cause pulmonary edema.
Ingestion: Corrosive. Swallowing can cause severe burns of the mouth, throat, and stomach, leading to death. Can cause sore throat, vomiting, diarrhea. May cause violent gastroenteritis, peripheral vascular collapse, dizziness, intense thirst, muscle cramps, shock, coma, abnormal bleeding, fever, liver damage and acute renal failure.
Skin Contact: Corrosive. Symptoms of redness, pain, and severe burn can occur. Dusts and strong solutions may cause severe irritation. Contact with broken skin may cause ulcers (chrome sores) and absorption, which may cause systemic poisoning, affecting kidney and liver functions. May cause skin sensitization.
Eye Contact: Corrosive. Contact can cause blurred vision, redness, pain and severe tissue burns. May cause corneal injury or blindness.
Chromic acid Exposure: Repeated or prolonged exposure can cause ulceration and perforation of the nasal septum, respiratory irritation, liver and kidney damage and ulceration of the skin. Ulcerations at first may be painless, but may penetrate to the bone producing "chrome holes." Known to be a human carcinogen.
Aggravation of Pre-existing Conditions: Persons with pre-existing skin disorders, asthma, allergies or known sensitization to chromic acid or chromates may be more susceptible to the effects of this material.
Want to learn more information about Chromic acid, you can access the guidechem.com. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
2014年1月7日星期二
New study on Diethylamine
Diethylamine is a secondary amine with the molecular structure CH3CH2NHCH2CH3 (also written as C4H11N). It is a flammable, strongly alkaline liquid. It is miscible with water and ethanol. It is a colorless liquid which often appears brown due to impurities. It is volatile and has a strong unpleasant odor, the Molecular Weight is 73.14, and CAS Registry Number is 109-89-7.
Topical diclofenac Diethylamine 1.16% gel is an NSAID that is clinically proven to be effective and well tolerated in acute and chronic musculoskeletal conditions. Applied topically, diclofenac penetrates the skin barrier to reach joints, muscles and synovial fluid. It preferentially distributes and persists in the target inflamed tissues, achieving a sufficiently high concentration to exert local therapeutic activity.
Therefore, this randomized, double-blind, placebo-controlled study aimed to assess its efficacy and safety in the treatment of acute NP. The primary objective of the study was to assess the efficacy of Diethylamine(CAS NO:109-89-7) 1.16% gel compared with placebo gel in the treatment of acute NP in terms of pain-on-movement at 48 h (Day 3) from baseline. Secondary objectives included the effect of Diethylamine 1.16% gel on pain-at-rest (PAR), functional impairment (using the neck disability index, NDI), patients’ global assessment of treatment efficacy and safety following application for 5 days.
The clinical study was designed, implemented and reported in accordance with the International Conference on Harmonization Harmonized Tripartite Guidelines for Good Clinical Practice and with the ethical principles laid down in the Declaration of Helsinki. The study protocol, protocol amendment and associated documents were reviewed by an Independent Ethics Committee in Germany. Informed consent was obtained from each subject in writing before randomization and the rights of subjects were protected.
The primary efficacy variable was POM after 48 h. Secondary efficacy variables included POM at all other visits, PAR and NDI score at Days 2, 3 and 5, response to treatment, early response to treatment, global assessment of treatment efficacy at Days 3 and 5 and use of rescue medication.
In total, 72 subjects were randomized to treatment between April 2011 and July 2011; 36 to Diethylamine 1.16% gel and 36 to placebo gel. All 72 patients completed the study and were included in the ITT population. The mean age was 33.8 years, with an almost equal number of males and females, and all subjects were Caucasian.
Overall, subjects had neck pain at baseline for about 10 days, an NDI score (24.5) midway the best and worst outcomes (0, 50), mild-to-moderate PAR (40.6 mm) and severe POM (75.5 mm). The treatment groups did not differ appreciably on any demographic or baseline neck pain characteristics. In particular, POM in the Diethylamine 1.16% gel and placebo groups were comparable at baseline (77.2 mm vs. 73.8 mm, respectively).
Want to learn more information about Diethylamine, you can access the guidechem.com.
Topical diclofenac Diethylamine 1.16% gel is an NSAID that is clinically proven to be effective and well tolerated in acute and chronic musculoskeletal conditions. Applied topically, diclofenac penetrates the skin barrier to reach joints, muscles and synovial fluid. It preferentially distributes and persists in the target inflamed tissues, achieving a sufficiently high concentration to exert local therapeutic activity.
Therefore, this randomized, double-blind, placebo-controlled study aimed to assess its efficacy and safety in the treatment of acute NP. The primary objective of the study was to assess the efficacy of Diethylamine(CAS NO:109-89-7) 1.16% gel compared with placebo gel in the treatment of acute NP in terms of pain-on-movement at 48 h (Day 3) from baseline. Secondary objectives included the effect of Diethylamine 1.16% gel on pain-at-rest (PAR), functional impairment (using the neck disability index, NDI), patients’ global assessment of treatment efficacy and safety following application for 5 days.
The clinical study was designed, implemented and reported in accordance with the International Conference on Harmonization Harmonized Tripartite Guidelines for Good Clinical Practice and with the ethical principles laid down in the Declaration of Helsinki. The study protocol, protocol amendment and associated documents were reviewed by an Independent Ethics Committee in Germany. Informed consent was obtained from each subject in writing before randomization and the rights of subjects were protected.
The primary efficacy variable was POM after 48 h. Secondary efficacy variables included POM at all other visits, PAR and NDI score at Days 2, 3 and 5, response to treatment, early response to treatment, global assessment of treatment efficacy at Days 3 and 5 and use of rescue medication.
In total, 72 subjects were randomized to treatment between April 2011 and July 2011; 36 to Diethylamine 1.16% gel and 36 to placebo gel. All 72 patients completed the study and were included in the ITT population. The mean age was 33.8 years, with an almost equal number of males and females, and all subjects were Caucasian.
Overall, subjects had neck pain at baseline for about 10 days, an NDI score (24.5) midway the best and worst outcomes (0, 50), mild-to-moderate PAR (40.6 mm) and severe POM (75.5 mm). The treatment groups did not differ appreciably on any demographic or baseline neck pain characteristics. In particular, POM in the Diethylamine 1.16% gel and placebo groups were comparable at baseline (77.2 mm vs. 73.8 mm, respectively).
Want to learn more information about Diethylamine, you can access the guidechem.com.
2014年1月6日星期一
Give you the summary of Thiophene-2-ethylamine
Basic information:
IUPAC Name: 2-thiophen-2-ylethanamine
Empirical Formula: C6H9NS
Molecular Weight: 127.2074
Index of Refraction: 1.567
Molar Refractivity: 37.72 cm3
Molar Volume: 115.4 cm3
Surface Tension: 43.3 dyne/cm
Density: 1.102 g/cm3
Flash Point: 74.6 C
Enthalpy of Vaporization: 43.59 kJ/mol
Boiling Point: 199.7 C at 760 mmHg
Vapour Pressure: 0.337 mmHg at 25C
Storage temp: Refrigerator (+4 C)
Sensitive: Air Sensitive
Appearance: colorless to yellow liquid
EINECS:250-196-9
CAS Registry Number:30433-91-1
Usages of Thiophene-2-ethylamine:
Thiophene-2-ethylamine is lipid-lowering drugs, platelet aggregation inhibitors, cardiovascular vasodilators, 5-lipoxygenase inhibitors and a variety of antimicrobial drugs and other biologically active drug intermediates, mainly used for the synthesis of cardiovascular and cerebrovascular disease drugs ticlopidine hydrochloride. As downstream drug development, this compound paid more attention to the fine chemical intermediates.
In commercial Thiophene-2-ethylamine(CAS NO:30433-91-1) can be prepared by the reaction of butane and sulfur. Thiophenes are also prepared by the reaction of diketones with Lawesson's reagent. This compoud and its derivatives exist in petroleum or coal. It is used as a solvent and chemical intermediate. Its derivatives are used in manufacturing dyes, aroma compounds and pharmaceuticals. Thiophene-2-ethylamine is used as an intermediate to manufacture pharmaceuticals such as antiplatelet drug (Clopidogrel, Ticlopidine) used to lessen the chance of heart attack or stroke.
MSDS of Thiophene-2-ethylamine
1.Potential Health Effects
Eye: Causes eye irritation. May cause chemical conjunctivitis.
Skin: Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Can produce delayed pulmonary edema.
Chronic: No information found.
2.First Aid Measures
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Supply information in guidechem
1.AOPHARM
Thiophene-2-ethylamine
Updatetime:Jan 06 2014
Purity:99%
DetailDesc:Pale yellow clear liquid, long buy become red
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd.
2.Capot Chemical Co., Ltd.
Thiophene-2-ethylamine
Updatetime:Dec 31 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:127.21,C6H9NS
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road
Want to learn more information about Thiophene-2-ethylamine, you can access the guidechem.com.Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
IUPAC Name: 2-thiophen-2-ylethanamine
Empirical Formula: C6H9NS
Molecular Weight: 127.2074
Index of Refraction: 1.567
Molar Refractivity: 37.72 cm3
Molar Volume: 115.4 cm3
Surface Tension: 43.3 dyne/cm
Density: 1.102 g/cm3
Flash Point: 74.6 C
Enthalpy of Vaporization: 43.59 kJ/mol
Boiling Point: 199.7 C at 760 mmHg
Vapour Pressure: 0.337 mmHg at 25C
Storage temp: Refrigerator (+4 C)
Sensitive: Air Sensitive
Appearance: colorless to yellow liquid
EINECS:250-196-9
CAS Registry Number:30433-91-1
Usages of Thiophene-2-ethylamine:
Thiophene-2-ethylamine is lipid-lowering drugs, platelet aggregation inhibitors, cardiovascular vasodilators, 5-lipoxygenase inhibitors and a variety of antimicrobial drugs and other biologically active drug intermediates, mainly used for the synthesis of cardiovascular and cerebrovascular disease drugs ticlopidine hydrochloride. As downstream drug development, this compound paid more attention to the fine chemical intermediates.
In commercial Thiophene-2-ethylamine(CAS NO:30433-91-1) can be prepared by the reaction of butane and sulfur. Thiophenes are also prepared by the reaction of diketones with Lawesson's reagent. This compoud and its derivatives exist in petroleum or coal. It is used as a solvent and chemical intermediate. Its derivatives are used in manufacturing dyes, aroma compounds and pharmaceuticals. Thiophene-2-ethylamine is used as an intermediate to manufacture pharmaceuticals such as antiplatelet drug (Clopidogrel, Ticlopidine) used to lessen the chance of heart attack or stroke.
MSDS of Thiophene-2-ethylamine
1.Potential Health Effects
Eye: Causes eye irritation. May cause chemical conjunctivitis.
Skin: Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Can produce delayed pulmonary edema.
Chronic: No information found.
2.First Aid Measures
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Supply information in guidechem
1.AOPHARM
Thiophene-2-ethylamine
Updatetime:Jan 06 2014
Purity:99%
DetailDesc:Pale yellow clear liquid, long buy become red
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd.
2.Capot Chemical Co., Ltd.
Thiophene-2-ethylamine
Updatetime:Dec 31 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:127.21,C6H9NS
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road
Want to learn more information about Thiophene-2-ethylamine, you can access the guidechem.com.Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.
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