Clinical studies on the usages of DL-Phenylalanine

Phenylalanine, which is an alpha (essential) amino acid, it is white powder with the Molecular Formula:C9H11NO2 and Molecular Weight:165.19. It is stable in and incompatible with strong oxidizing agents. The CAS Registry Number is 150-30-1. It is found in both naturally occurring (L-phenylalanine) and artificially synthesized (D-phenylalanine) forms. 

The two different forms of phenylalanine have different medical applications, and the derived DL form has the properties of both, and is, as such, used in the treatment of a number of conditions. As with all phenylalanine, DL-phenylalanine should not be consumed by people with phenylketonuria, a disease which causes the body to be unable to use phenylalanine.

DL-Phenylalanine(CAS NO:150-30-1) is used in the manufacture of food and drink products and sold as a nutritional supplement for its reputed analgesic and antidepressant effects. It is a direct precursor to the neuromodulator phenylethylamine, a commonly used dietary supplement. But in this article I will show you medicial use of this compound.

D-phenylalanine (but not L-phenylalanine) has been proposed to treat chronic pain, but so far the studies have not shown good evidence that it works. Two studies that appeared to show positive results had flaws that made the findings unreliable. Other clinical studies have found it to be no more effective than placebo in reducing pain. No randomized controlled trials have been done in the past 20 years to study any possible benefit of taking it for chronic pain, so more research is needed to determine its safety and effectiveness.

Some clinical studies suggest that DL-Phenylalanine may be helpful as part of a comprehensive therapy for depression. However, most of the studies were done in the 1970s and 1980s and were not rigorously tested. People have reported that their mood improved when they took this compound. Researchers think this is because it increases production of brain chemicals, such as dopamine and norepinephrine. More research is needed to tell whether phenylalanine has any real effect on depression.

Some preliminary studies have found that L-phenylalanine strengthens the effect of UVA radiation for people with vitiligo. Vitiligo is a condition where irregular depigmentation causes white patches of skin. It may lead to some darkening or repigmentation of the white patches, particularly on the face. However, more research is needed to see whether this compound is truly effective.

One animal study suggests that D-phenylalanine may improve rigidity, walking disabilities, speech difficulties, and depression associated with Parkinson's disease. However, there is no evidence yet whether D-phenylalanine would have the same effect in humans.

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