Acycloguanosine used as a medicine

1. Indications of acycloguanosine

(1) Herpes simplex virus infection: used for oral genital herpes virus infection of primary and recurrent cases; recurrent oral this product used to prevent cases. Injection for people has immunodeficiency. Prevention and treatment of primary and recurrent mucocutaneous infection and recurrent cases; also used in the treatment of herpes simplex encephalitis.

(2) Herpes zoster: oral treatment for immunocompetent individuals with herpes and immunodeficiency mild case. Injection is just for the treatment of severe herpes patients with immunodeficiency.

(3) Treatment of immunodeficiency varicella.

(4) Local for early genital herpes infection and immunodeficiency caused by herpes simplex virus self limiting mucocutaneous herpes simplex initial treatment and relapse cases.

(5) Treatment of acute retinal necrosis with its sodium salt

2. Pharmacological mechanism of acycloguanosine

Acycloguanosine is a kind of disease resistant poison. It has inhibition on herpes simplex virus, varicella zoster virus, cytomegalovirus and so on in vitro. This good entering the herpes virus infected cells, and deoxynucleoside competition virus thymidine kinase or cell kinase, then through two ways to inhibit virus replication:

(1) Disturbance of virus DNA polymerase, suppression of viral replication.

(2) In the DNA polymerase function, combined with the growth of the DNA chain, DNA chain elongation caused by interruption.

Acycloguanosine has a special affinity for the virus, but to a mammalian host cell toxicity.

3. Adverse reactions

(1) The common adverse reactions

The injection site or phlebitis inflammation, skin itching or hives, have a fever, rash, headache, nausea, mild,Vomiting, diarrhea, urinary protein, blood urea nitrogen and serum creatinine values increased, abnormal liver function such as serum aminotransferase, lactate dehydrogenase, alkaline phosphatase, total bilirubin slightly higher.

(2) Uncommon adverse reactions

Acute renal insufficiency, white and red blood cells decreased, decreased hemoglobin, neutropenia, idiopathic thrombocytopenic purpura, cholesterol, triglyceride, hematuria, hypotension, Dohan, palpitations, difficulty breathing, chest tightness.

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