An interesting story about Acetylsalicylic acid

Acetylsalicylic Acid, also known by trade name Aspirin, is an acetyl derivative of salicylic acid that is a white, crystalline, weakly acidic substance, with melting point 137°C. Its CAS NO is 50-78-2.

Today, Acetylsalicylic Acid is one of the most widely used medications in the world, estimated 40,000 tones of Acetylsalicylic Acid being consumed each year. In countries where Acetylsalicylic Acid is a registered trademark owned by Bayer, the generic term is acetylsalicylic acid (ASA).

      

Today, most of us well know of Acetylsalicylic Acid, but you may not hear about the history of Acetylsalicylic Acid. The origin of Acetylsalicylic Acid has a long history; this article will give you the answer.

In 2300 years ago, the founder of Western medicine, the Greek physiological and medical scientist F Pokela Di has found, water willow leaf and leather goods has analgesic and antipyretic effect, but he didn’t clear its active ingredients then.

In 1827, British scientists first discovered LAROX willow contains a substance called salicin. In 1853, the German chemist Jerg first synthetic salicylates predecessor -- Pure salicylic acid, it has antipyretic analgesic effect, but highly toxic, has strong stimulation to the stomach. In 1897, another German chemist Hoffman, for relieving his father’s rheumatic pain, he changed the pure salicylic acid to acetylsalicylic acid.

Since then, the acetylsalicylic acid has been recognized by public, and it was gradually used down, which is now known as Acetylsalicylic Acid. It remains the properties of pure salicylic acid, but its toxicity and adverse reaction was greatly reduced.

Because Acetylsalicylic Acid has magical effect on the fever, the demand for Acetylsalicylic Acid is huge. Very soon, the German chemist Bayer founded the manufacturing process with industrial methods of Acetylsalicylic Acid in 1899, started mass production of Acetylsalicylic Acid, and sell well all over the world.

China began production Acetylsalicylic Acid in 1958. Now, Acetylsalicylic Acid has been used for hundreds of years, it becomes one of the three major classical drugs in history of medicine.

It remains most widely used for antipyretic, analgesic and anti-inflammatory in the world. Acetylsalicylic Acid is always used as the comparison and evaluation of standard preparation of other drugs. The medicine can be used for antipyretic analgesic and anti-inflammatory (fever, toothache, pain, acute rheumatic fever, diagnosis and differential diagnosis of rheumatic and rheumatoid arthritis).

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