What is 2,4-Dichloropyridine used for?

2,4-Dichloropyridine is a very useful intermediates, mainly used in pharmaceutical and pesticide synthesis. Some of these products have been used for household chemicals and crops, individual product market prospects.

Synthesis of 2,4-Dichloropyridine(CAS NO: 26452-80-2) began in 1891. In more than one century, a number of new synthetic methods have developed. From the raw materials used can be grouped into three categories: (1) pyridine derivatives chloride; (2) the direct chlorination of pyridine; (3) Other.

Ours is a large population and a large agricultural country, a vast potential market for pharmaceuticals and pesticides, concerns the progress in these two areas has important practical significance. This article will briefly describe 2,4-Dichloropyridine in medicine and agriculture purposes

1.   2,4-Dichloropyridine used in synthetic drugs

The chlorine atomic in 2,4-Dichloropyridine can be substituted by a nucleophile, such as a phenyl acetonitrile, and 2 - chloropyridine-pyridyl of a strong base (Pyridylation), then alkylation, hydrolysis and decarboxylation, to produce anti-histamines - non-Nepalese December Ming. Antiarrhythmic drug - disopyramide can also be produced similarly.

2,4-Dichloropyridine oxidized to give 2 - chloro-pyridine nitrogen oxides, which, after reaction with sodium hydrosulfide was pyrithione. Zinc pyrithione as fungicides, mainly used in shampoos. 2 - chloro-pyridine is synthesized mold pyrithione net (2-mercaptopyridine N-oxide sodium), preservatives, and other intermediates.

2.   2,4-Dichloropyridine used for synthetic pesticides

The nitrogen oxides of 2,4-Dichloropyridine through nitrification to give 2 - chloro-4 - nitro pyridine, after reduction to give 2 - chloro-4 - aminopyridine, which is preparing Forchlorfenuron essential intermediate body.

Forchlorfenuron is a new class of high activity, low toxicity, broad-spectrum plant growth regulator, with cell division activity, its mechanism and purine cytokinins (kinetin, zeatin) the same, but more active than they are high 10 ~ 100 times. Practice has proved that Forchlorfenuron for many species of plants have very far-reaching effects, flowery front with time, can induce parthenocarpy into seedless fruit, increase crop fruit set; flowering or after flowering, when used to increase the fruit, thus significantly increased crop yield and fruit quality, has been used in food crops, melons, fruits, vegetables, some crops and ornamental plants.

2,4-Dichloropyridine further chlorination can be obtained in a high yield of 2,6 - dichloro-pyridine and various polychlorinated pyridine substituted. 2,6 - dichloro-pyridine used to take antibiotics (enoxalin); nitrogen stabilizer tetrachloro grass and (Nitrapyrin); 2,3,5,6 - tetrachloropyridine itself with herbicidal properties, it is made insecticide chlorpyrifos and chlorine grass and herbicide b (triclopyr) intermediates; 2,3,5 - trichloro-pyridine is pesticide intermediates.

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