The medicine, D-Glucitol

Name of this medicine: D-Glucitol

Alias of this medicine: Cholaxine、Sorbitol、D-Sorbitol、Diakarmon、Karion、L-Gulitol、Neosorb、Sorbit

Pharmacological action of D-Glucitol: D-Glucitol is similar to mannitol, because most of D-Glucitol convert into glycogen after being into the body and reduce its high permeability, so the role of weak than mannitol. D-Glucitol (CAS NO : 50-70-4) can increase the osmotic pressure of plasma and tissue dehydration, reducing intracranial pressure, and reduce the intraocular pressure. From the glomerular filtration, due to high osmotic pressure in the proximal tubules produced a diuretic effect.

Clinical application of D-Glucito: For the prevention of traumatic brain injury, cerebral edema, acute renal failure, glaucoma and acute oliguric renal failure.

The taboos of D-Glucitol:

(1) Someone who suffer with acute, chronic renal insufficiency disable.

(2) People who suffer with intracranial hemorrhage were banned.

Adverse reactions:

(1) The most common adverse reactions are “water and electrolyte disorders”.

---The rapid intravenous injection of D-Glucitol, the D-Glucitol accumulation in the body can cause blood volume rapidly growing, leading to heart failure (especially the cardiac function damage), dilutional hyponatremia, even can cause hyperkalemia.

---Excessive and inappropriate diuresis leads to reduced blood volume, increase oliguria.

(2) Chills, fever.

(3) The dysuria.

(4) Thrombophlebitis.

(5) Sorbitol extravasation can cause tissue edema, necrosis of skin.

(6) Allergic rashes, hives, difficulty breathing, anaphylactic shock.

(7) The dizziness, blurred vision.

(8) The hyperosmolality induced thirst.

(9) Osmotic nephrosis, mainly in the large dose of rapid intravenous drip. The mechanism has not been fully elucidated, possible renal tubular fluid pressure rise too high caused by D-Glucitol, resulting in renal tubular epithelial cell > injury. Pathological manifestations of renal tubular epithelial cell swelling, vacuolization, clinically reduced urine output, and acute renal failure. Osmotic nephrosis is common in the elderly decreased renal blood flow and low sodium, dehydrated patients.

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