Something you should minder about 4-Hydroxypyrazolo[3,4-d]pyrimidine

4-Hydroxypyrazolo[3,4-d]pyrimidine is the only xanthine oxidase inhibitor. It prevents metabolism of hypoxanthine and xanthine to uric acid, uric acid reduction, the blood and urine levels of uric acid is reduced to below the level of solubility, to prevent the formation of uric acid and the crystals deposited in the joints and other tissues, but also help organize gout uric acid crystals within the re-dissolve.

4-Hydroxypyrazolo[3,4-d]pyrimidine (CAS NO: 315-30-0) is also by hypoxanthine - guanine phosphoribosyl-converting enzyme inhibition of nucleic new purine synthesis in vivo. Clinical will use it for primary and secondary hyperuricemia (especially caused by excessive production of uric acid hyperuricemia), recurrent or chronic gout, tophi, uric acid kidney stones, and (or) uric acid nephropathy, renal insufficiency hyperuricemia. But 4-Hydroxypyrazolo[3,4-d]pyrimidine has a higher incidence of adverse reactions, and some more serious reactions, such as hair loss, liver toxicity, interstitial nephritis. There have been several cases of foreign patients taking this occurred during the sudden death of unknown cause were reported. To do drug safety, the use of 4-Hydroxypyrazolo[3,4-d]pyrimidine should be aware of the following issues.

1. Severe liver dysfunction and significantly lower blood cells, pregnant women and lactating women disabled.

2. 4-Hydroxypyrazolo[3,4-d]pyrimidine must be performed by a small dose and gradually increasing to an effective amount to maintain normal serum uric acid and uric acid levels, then gradually reducing, with the minimum effective dose to maintain a long time. Adult initial dose once 50mg, day 1 or 2 times a week can increase 50 ~ 100mg, to day 200 ~ 300mg, 2 to 3 times service. Biweekly measurement of blood and urine levels of uric acid, such as reached normal levels, then no incremental, such as still too high can be incremented, but the day the maximum amount shall not exceed 600mg.

3. Children's treatment of secondary hyperuricemia usual dose: 6 years of age each 50mg, day 1 to 3 times; 6 to 10 years old, a 100mg, day 1 to 3 times the dose may be adjusted as appropriate. Kidney, liver dysfunction medication and the elderly should be cautious, and should reduce the daily dose.

4. Medication should drink more water, and to facilitate the neutral or alkaline urine excretion of uric acid.

5. 4-Hydroxypyrazolo[3,4-d]pyrimidineis a higher incidence of rash with ampicillin with the use of increased incidence of rash, especially in patients with hyperuricemia. In use, the emergence of widespread and persistent skin rash, after symptomatic treatment ineffective and there is increasing trend, must be discontinued; leukopenia, thrombocytopenia, anemia or bone marrow suppression, should consider stopping.

6. 4-Hydroxypyrazolo[3,4-d]pyrimidine can not control acute gouty arthritis symptoms of inflammation, not as anti-inflammatory drugs used because the product when prompted re-dissolve uric acid crystals can be re-induce and aggravate arthritis acute symptoms. It must be gouty arthritis symptoms disappeared after acute inflammation (usually about two weeks after the onset) party began to apply.

7. Furthermore, it should pay attention to, drinking, chlorthalidone, ethacrynic acid, furosemide, metolazone, pyrazinamide or thiazide diuretics may increase serum uric acid. For hypertension or in patients with poor kidney function, the goods and with the use of thiazide diuretics, there is renal failure and the emergence of allergies may be. Taking medication during drug uric acid, may increase the possibility of the formation of kidney stones. The goods and anticoagulant drugs, azathioprine or mercaptopurine, cyclophosphamide with the use of the latter's effects and adverse reactions enhanced dose should be taken to reconcile toxicity.

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