Ceftriaxone disodium salt hemiheptahydrate
is a third-generation cephalosporin. Against Enterobacteriaceae have strong
activity. Against Escherichia coli, Klebsiella pneumoniae, Enterobacter
aerogenes, Citrobacter fluorine labor, indole-positive Proteus, and Serratia
spp Prussian Vuitton, the MIC90 is from 0.12 to 0.25mg. Enterobacter cloacae,
Acinetobacter and Pseudomonas aeruginosa are poor sensitivity to Ceftriaxone
disodium salt hemiheptahydrate.
Ceftriaxone disodium salthemiheptahydrate has a strong antibacterial effect on Haemophilus
influenzae, Neisseria gonorrhoeae and Neisseria meningitides. On the hemolytic
streptococcus and pneumococcus Ceftriaxone disodium salt hemiheptahydrate also
has a good effect. Against Staphylococcus aureus, MIC is 2 to 4mg / L.
Methicillin-resistant staphylococci and enterococci resistant to Ceftriaxone
disodium salt hemiheptahydrate. Most of Bacteroides fragilis resistant to
Ceftriaxone disodium salt hemiheptahydrate.
Ceftriaxone disodium salt hemiheptahydrate
used for curing lower respiratory tract infections, urinary tract, biliary
tract infections, and intra-abdominal infections, pelvic infections, skin and
soft tissue infections, bone and joint infections, septicemia, meningitis, and
operative infection, which is caused sensitive bacteria. This product is simply
a single dose to treat gonorrhea.
The adverse reactions of Ceftriaxone
disodium salt hemiheptahydrate are related to dose and treatment. Local
reactions have phlebitis (1.86%), in addition may have a rash, itching, fever,
bronchospasm, and serum sickness and other allergic reactions (2.77%), headache
or dizziness (0.27%), diarrhea, nausea, vomiting, abdominal pain, colitis,
jaundice, flatulence, taste disturbance, indigestion and other gastrointestinal
reactions (3.45%). Laboratory abnormalities are about 19%, of which 14%
hematological abnormalities, including increased eosinophils, platelets
increase or decrease and leukopenia. Liver and kidney dysfunction was 5% and
1.4%.
For pregnant and lactating women, although
the application of cephalosporins in question has not been reported, its
application must still weigh. The drug safety of Newborns (birth weight less
than 2kg) has not been established. Jaundice of the newborn or neonatal
jaundice serious tendency should be used with caution or avoid Ceftriaxone
disodium salt hemiheptahydrate. Unless elderly patients weakness, malnutrition
or severe renal impairment, the elderly applications generally do not need to
adjust the dose of Ceftriaxone disodium salt hemiheptahydrate.
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