What is Vincristine sulfate?

Basic information:

English name: Vincristine Sulphate

English Synonyms: Vincristine Sulfate, Apocynaceae sp.; Vincristine Sulphate; Vincristine sulfate salt; 22-Oxovincaleukoblastine sulfate salt; Leurocristine sulfate salt

Specification: 99%, pharmaceutical grade

Formula: 6H56N4O10.H2SO4

Purity: 99% min

Melting point: 273-281 ℃

Molecular Weight: 923.04

CAS No. : 2068-78-2

Properties: white or white loose-like or amorphous solid, hygroscopic, easy to turn yellow when exposed to light or heat.

Applicable symptoms:

1. Acute leukemia, especially in children with acute leukemia, acute lymphoblastic leukemia, a significant effect.

2. Malignant lymphoma.

3. Germ cell tumors.

4. Small cell lung cancer, Ewing's sarcoma, Wilms tumor, neuroblastoma.

5. Breast cancer, chronic lymphocytic leukemia, gastrointestinal cancer, melanoma and multiple myeloma.

Dosage: Adult dose of 1 ~ 2mg (or 1.4mg/m2) is not greater than the maximum 2mg, older than 65 years, the maximum per 1mg. Children 75μg/kg or 2.0mg/m2, weekly intravenously or into. MDT is once every 2 weeks as a cycle.

Adverse reactions:

1. Dose-limiting toxicity is the nervous system toxicity, mainly caused by peripheral nerve symptoms, such as a finger, neurotoxicity, and cumulative volume. Toe numbness, tendon reflexes slow or disappear, peripheral neuritis. Abdominal pain, constipation, paralytic ileus are occasionally. Motor nerves, sensory nerves and brain can also be broken ring and produce symptoms. Neurotoxicity often occurs in more than 40 years of age, children and well tolerated in adults, malignant lymphoma patients had a tendency to neurotoxicity than other cancer patients.

2. Mild bone marrow suppression and gastrointestinal reactions.

3. There are local tissue irritation, liquid can not leak, or can cause local necrosis.

4. Visible hair loss, occasional blood pressure changes.

Considerations:

1. Vincristine Sulphate is only for intravenous injection, leakage in the subcutaneous can lead to tissue necrosis, cellulitis. Once the leak or suspected leak, the infusion should be stopped immediately, and dealt with it accordingly (refer to leakage of nitrogen mustard treatment).

2. Prevent Vincristine Sulphate splashed into eyes, in the event immediately with plenty of saline, after dexamethasone ointment protection.

3. When inject Vincristine Sulphate into the vein to avoid direct sunlight.

4. Abnormal liver function, reducing the dosage of incristine Sulphate.

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