Some matters need attention about Trimethoprim

Trimethoprim (INN) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.

It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Trimethoprim was formerly marketed by GlaxoSmithKline under trade names including Proloprim, Monotrim and Triprim; but these trade names have been licensed to various generic pharmaceutical manufacturers. In clinical use it is often abbreviated TRI or TMP; its common laboratory abbreviation is W, and CAS NO is 738-70-5.

Although Trimethoprim has many uses, but what the most frequently use is Treating infections caused by certain bacteria. Trimethoprim is an antibiotic. It works by killing sensitive bacteria.

Trimethoprim also has some side affects, not every people can use this medicine. If you or someone you know who has follow conditions, please don’t use Trimethoprim.

1. If you are allergic to any ingredient in trimethoprim or to similar medicines, please don’t use it.

2. If you are taking dofetilide, please stop use trimethoprim, because if they were together, something you never hoped would be happen.

3. If you have anemia caused by low levels of folate in the blood, you can not use it by yourself .Contact your doctor or health care provider right away if any of these apply to you, please.

Besides these suggestions, you also should these following things, before using trimethoprim.

1. Because some medical conditions may interact with trimethoprim, tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

(1) If you are pregnant, planning to become pregnant, or are breast-feeding.

(2) If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.

(3) If you have allergies to medicines, foods, or other substances.

(4) If you have liver or kidney problems or blood problems (eg, anemia, porphyria).

(5) If you have or are at risk for low levels of folate in the blood (eg, you have alcoholism, are elderly, you do not absorb nutrients from food properly, you are in a poor nutritional state, you are taking medicine for seizures).

2. Some MEDICINES MAY INTERACT with trimethoprim. Tell your health care provider if you are taking any other medicines, especially any of the following:

(1) Dofetilide because of the risk of severe heart problems may be increased by trimethoprim.

(2 )Methotrexate, phenytoin, or sulfones (eg, dapsone) because of their actions and the risk of their side effects may be increased by trimethoprim.

(3) Cyclosporine because of its effectiveness may be decreased and the risk of liver side effects may be increased by trimethoprim.

This may not be a complete list of all interactions that may occur. Ask your health care provider if trimethoprim may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

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