1,3-Dimethoxy benzene information

1,3-Dimethoxy benzene, which is also known as Dimethyl resorcinol, m-Dimethoxybenzene, Resorcinol dimethyl ether, Dimethylresorcinol, 3–Methoxyanisole, Dimethylether resorcinolu(Czech), 1,3-Dimethoxybenzeen, 1,3-Dimethoxybenzene and Dimethylether resorcinolu. The CAS NO of 1,3-Dimethoxy benzene is 151-10-0, MF is C8H10O2, MW is 138.1638.

The density of 1,3-Dimethoxy benzene is 1.055. Boiling point is 85-87 degree. Refractive index is 1.523-1.525, flash point is 87 degree, and relative density is 1.005g/cm3. It is a kind of colorless and transparent liquid. There are orange blossom aroma ether, slightly spicy taste

1,3-Dimethoxy benzene is used for organic synthesis intermediates, and benzoyl chloride in three aluminum chloride catalyst for mandrax-Crafts reaction, to be 2,4-dimethoxy benzophenone. It is the UV absorber UV-9 intermediates. 

A Typical Iodination Procedure Using Micromixing. 

A solution of 1,3-dimethoxybenzene (112 mg, 0.811 m mol) in CH3CN and an I+ solution (8 mL, cooled at 0 ℃), generated from I2 (127 mg, 0.500 m mol) using the electrochemical method described above, were simultaneously introduced to an IMM single mixer (version 2) having a Si inlet (channel width = 50 μm), which was dipped in a coolant at 0 ℃, using syringe pumps (flow rate is 3.0 mL/min each). Then, the reaction mixture coming out from the outlet of the micromixer was collected with a 100 mL round bottom flask, containing sat. NaHCO3 (30 mL), sat. NaS2O3 (1 mL), and Et2O (30 mL), with magnetic stirring. 

The organic layer was separated and the solvent was removed under reduced pressure. The residue 
was quickly filtered through a short column (10 cm) of silica gel to remove Bu4NBF4. The silica gel was washed with Et2O (100 mL). The solvent was removed under reduced pressure and the residue was dissolved in hexane (50 mL). The organic phase was washed with sat. NaHCO3 (30 mL) and then was separated. The solvent was removed to give a crude product (204 mg). Yields of 4-iodo-1,3-dimethoxybenzene (monoiodo product) and 4,6-diiodo-1,3- dimethoxybenzene (diiodo product) were determined by GC analysis: 4-iodo-1,3-dimethoxybenzene 78% (167 mg, 0.632 m mol): 4,6-diiodo-1,3- dimethoxybenzene 4% (13 mg, 0.033 m mol).

First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. 

Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. 

Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. 

Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. 


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