Usages and effects of Mifepristone

Mifepristone is a synthetic steroid compound used as a pharmaceutical. It is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. Mifepristone is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing's Syndrome (due to ectopic/neoplastic ACTH/Cortisol secretion).

During early trials, it was known as RU-38486 or simply RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed—often amid controversy. It is marketed under tradenames Korlym and Mifeprex, according to FDA Orange Book. Some examples of such drugs include ibuprofen, aspirin, and naproxen. This medication is often used for people that are at an especially high risk of experiencing ulcers.

The Primary Use
Misoprostol(CAS NO.:84371-65-3) is a medication that works to stop stomach ulcers from happening when individuals take NSAIDs. It reduces the chances of severe complications of ulcers, like bleeding. It functions by defending the lining of the stomach by reducing the levels of acid that come into contact with the lining.

Used as Abortion
A secondary use for this medication is for the termination of pregnancy, which is also known as abortion.An abortion is the termination of a pregnancy. Whenever possible, abortions should be performed by the ninth week of pregnancy in order to limit complications. There are risks involved at any time---during the procedure and afterward. Choosing abortion requires careful consideration. It is used alongside another drug, which is known as mifepristone, in order to end a pregnancy. Mifeprostone obstructs progesterone, which is a hormone that is necessary to keep a pregnancy going. This results in the shedding of the uterine lining, and the softening of the cervix, which could lead to bleeding. Then, misoprostol is administered, which causes the uterus to contract and causes the pregnancy to terminate itself within approximately 6 to 8 hours.

Help with Childbirth
Mifeprostone is also sometimes used in helping with childbirth, when the baby is being delivered. It can assist in inducing labor as well as cervical ripening. It also can help treat and manage serious bleeding that sometimes happens right about delivery. It is administered vaginally in those situations, and functions by enabling the muscles of the womb to contract.

Common Side Effects
In using Mifeprostone, it is possible to experience several common side effects. These common side effects include stomach cramps, diarrhea, and nausea. These side effects are considered to be minor, because they usually rapidly subside (as the body adapts to the medicine). However, if you experience any of these side effects, and they intensify with time (as opposed to decreasing), talk with your doctor about them as soon as possible.

Severe Side Effects
Using Mifeprostone also could lead to some very uncommon, but simultaneously very severe side effects as well. If you have any of these side effects, you need to seek emergency medical attention (as they could result in potentially harmful consequences). These side effects are heavy or abnormal vaginal bleeding, and menstrual irregularities or problems.

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