Brief introduction about Trimethyl orthoformate

Basic information of Trimethyl orthoformate:

(1)Other Names: Methyl orthoformate;
(2)Appearance: Colorless liquid;
(3)PubChem: 9005;
(4)ChemSpider: 8655;
(5)Molecular formula: C4H10O3;
(6)Molar mass: 106.12 g•mol-1;
(7)CAS No.: 149-73-5;
(8)EINECS No.: 205-745-7.

Trimethyl orthoformate is a the simplest orthoester. It is a reagent used in organic synthesis for the introduction of a protecting group for aldehydes. The product of reaction of an aldehyde with trimethyl orthoformate is an acetal. In general cases, these acetals can be deprotected back to the aldehyde by using hydrochloric acid.Trimethyl orthoformate is a flammable, colorless liquid with a pungent odor, the smell is similar to the ether substance, but the fragrance is very short.

Trimethyl Orthoformate(TMOF) mainly as organic intermediates for: Pharmaceutical, Agrochemical, Spices Synthesis, A coating agent.In medicine it is mainly used for the synthesis of vitamin B1, sulfonamides, antibiotics, etc.; in coatings it used in polyurethane or epoxy coatings to prevent hydration and hardening due to dehydration; Trimethyl orthoformate is also used in perfumery synthesis. 

In case of fire or heat, a risk of fire and explosion may occur, Trimethyl orthoformate orally may cause breathing difficulties and muscle weakness symptoms.

Trimethyl Orthoformate should be stored in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Moisture sensitive.

Keep Trimethyl Orthoformate away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, combustible materials, acids.


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