Some researches of Quercetin dihydrate

Quercetin dihydrate which is also known as Quercetin, it is soluble in glacial acetic acid, alkaline solution is yellow, almost insoluble in water, ethanol taste bitter. It can be used as drugs, has a good expectorant, cough, and have some asthma. There are also some functions about lower blood pressure, increased capillary resistance, reducing capillary fragility, blood fat, expansion of coronary artery, increase coronary blood flow and so on. It also has a good function for the treatment of chronic bronchitis. Coronary heart disease and hypertension patients also had adjuvant therapy.

In this article, I will show you some Preliminary researches of Quercetin dihydrate(CAS NO.:6151-25-3).

Research on Antivira
Hyperoside (which is the 3-O-galactoside of Quercetin dihydrate) is a strong inhibitor of HBsAg and HBeAg secretion in 2.2.15 cells. Quercitrin and myricetin 3-O-beta-D-galactopyranoside inhibit HIV-1 reverse transcriptase, all with IC50 values of 60 μM. It can also inhibit reverse transcriptase, part of the replication process of retroviruses.The therapeutic relevance of this inhibition has not been established.

Research on Asthma
Quercetin dihydrate is an effective bronchodilator and helps reduce the release of histamine and other allergic or inflammatory chemicals in the body. It has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation.

Research on Cancer
Laboratory studies have investigated Quercetin dihydrate's potential for use in anti-cancer applications.The American Cancer Society says while this medicine "has been promoted as being effective against a wide variety of diseases, including cancer," and "some early lab results appear promising, as of yet there is no reliable clinical evidence that this medicine can prevent or treat cancer in humans." In the amounts consumed in a healthy diet, it "is unlikely to cause any major problems or benefits."

Research on Eczema
Serum IgE levels are highly elevated in eczema patients, and virtually all eczema patients are positive for allergy testing. Excessive histamine release can be minimized by the use of antioxidants. Quercetin dihydrate is frequently used therapeutically in allergic conditions, including asthma and hayfever, eczema, and hives.

Research on Inflammation
Several laboratory studies show Quercetin dihydrate may have anti-inflammatory properties,and it is being investigated for a wide range of potential health benefits.It has been reported to be of use in alleviating symptoms of pollinosis. An enzymatically modified derivative was found to alleviate ocular but not nasal symptoms of pollinosis.

Studies done in test tubes have shown Quercetin dihydrate may prevent immune cells from releasing histamines which might influence symptoms of allergies.A study with rats showed that this drug effectively reduced immediate-release niacin (vitamin B3) flush, in part by means of reducing prostaglandin D2 production. A pilot clinical study of four humans gave preliminary data supporting this.It may have properties of a calcineurin inhibitor, similar to cyclosporin A and tacrolimus, according to one laboratory study.

Research on Fibromyalgia
Quercetin dihydrate may be effective in the treatment of fibromyalgia because of its potential anti-inflammatory or mast cell inhibitory properties shown in laboratory studies.

Research on Metabolic syndrome
Quercetin dihydrate has been shown to increase energy expenditure in rats, but only for short periods (fewer than 8 weeks). Effects of this chemical on exercise tolerance in mice have been associated with increased mitochondrial biogenesis. In mice, an oral Quercetin dihydrate dose of 12.5 to 25 mg/kg increased gene expression of mitochondrial biomarkers and improved exercise endurance.

It has also been claimed that Quercetin dihydrate reduces blood pressure in hypertensive and obese subjects in whom LDL cholesterol levels were also reduced.In vitro studies showed Quercetin dihydrate and resveratrol combined inhibited production of fat cells and vascular smooth muscle cell proliferation.Supplements of this medicine with vitamin C and niacin does not cause any significant difference in body mass or composition[48] and has no significant effect on inflammatory markers, diagnostic blood chemistries, blood pressure, and blood lipid profiles.

Research on Monoamine-oxidase inhibitor
Possibly an active component of heather (Calluna vulgaris), Quercetin dihydrate was suspected from a bioassay test on crude extracts to selectively inhibit monoamine oxidase, possibly indicating pharmacological properties.

Want to learn more information about Quercetin dihydrate, you can access the guidechem.com.