Our body need L-Glutamine,N-ethyl-

L-Glutamine,N-ethyl- was discovered as a constituent of green tea in 1949 and was approved in Japan in 1964 for unlimited use in all foods, including chocolates, soft drinks, and herb teas, except infant foods. It also provides a unique umami (brothy or savory) taste and flavor to green tea infusion.

In 1950, the tea laboratory of Kyoto successfully separated L-Glutamine,N-ethyl- from gyokuro leaf, which has high L-Glutamine,N-ethyl- content. It is an analog to glutamine and glutamate, and can cross the blood–brain barrier. It is sold in the US as a dietary supplement, and is classified by the Food and Drug Administration (FDA) as a generally recognized as safe (GRAS) ingredient. However, the German Federal Institute for Risk Assessment (Bundesinstitut für Risikobewertung, BfR) has objected to the addition of isolated L-Glutamine,N-ethyl- to beverages.

L-Glutamine,N-ethyl-(CAS NO:3081-61-6) is an amino acid derived from another amino acid, glutamic acid. Glutamine plays a role in the health of the immune system, digestive tract, and muscle cells, as well as other bodily functions. It appears to serve as a fuel for the cells that line the intestines. Heavy exercise, infection, surgery, and trauma can deplete the body's L-Glutamine,N-ethyl- reserves, particularly in muscle cells.

The fact that L-Glutamine,N-ethyl- does so many good things in the body has led people to try L-Glutamine,N-ethyl- supplements as a treatment for various conditions, including preventing the infections that often follow endurance exercise, reducing symptoms of overtraining syndrome, improving nutrition in critical illness, alleviating allergies, and treating digestive problems.

Early studies of this chemical involved much larger doses than are found in an everyday cup of tea. Researchers wonder whether drinking tea might have the same effects found in those studies.However, one recent study by Unilever found that smaller doses typical of those found in a cup of tea did induce changes in alpha waves as shown by EEG. Alpha waves occur in the brain and are associated with relaxation.

As a naturally occurring amino acid, L-Glutamine,N-ethyl- is thought to be a safe supplement when taken at recommended dosages. There is strong evidence that this medicine is safe at levels up to 14 g per day, although higher dosages have been tested without apparent adverse effects. 

Nevertheless, those who are hypersensitive to monosodium glutamate (MSG) should use L-Glutamine,N-ethyl- with caution, as the body metabolizes it into glutamate. Also, because many anti-epilepsy drugs work by blocking glutamate stimulation in the brain, high dosages of L-Glutamine,N-ethyl- might conceivably overwhelm these drugs and pose a risk to people with epilepsy . 

In one case report, high doses of the supplement L-Glutamine,N-ethyl- (more than 2 g per day) may have triggered episodes of mania in two people not previously known to have bipolar disorder. In a small randomized trial including 30 older people,L-Glutamine,N-ethyl- did not cause any clinically significant changes in lab tests. The researchers did urge caution, though, since there were some statistically significant changes for certain kidney levels. 

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